| 2-苯基喹唑啉-4-酮的Vilsmeier反应研究 |
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| 引用本文： | 赵春红,李慎庆,吴斌,刘金浩,董丹丹,刘刚.2-苯基喹唑啉-4-酮的Vilsmeier反应研究[J].广州化工,2011(3):73-75. |
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| 作者姓名： | 赵春红 李慎庆 吴斌 刘金浩 董丹丹 刘刚 |
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| 作者单位： | 1. 鲁东大学化学与材料科学学院,山东烟台,264025
2. 桓台县第二中学,山东淄博,256400 |
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| 基金项目： | 山东省高等学校科技计划项目，鲁东大学2009年开放实验室项目和鲁东大学创新团队建设项目 |
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| 摘 要： | 以邻氨基苯甲酸、苯甲酸酐和乙酸为原料,经过绿色合成方法合成了2-苯基喹唑啉-4-酮,然后对2-苯基喹唑啉-4-酮进行了Vilsmeier反应研究。用IR对其结构进行了表征。考察了反应时间、反应温度和投料配比对Vilsmeier反应的影响。结果表明,反应时间为4 h,反应温度为80~90℃,原料POCl3与2-苯基喹唑啉-4-酮的摩尔比为1.5：1为最佳的反应条件,收率可达67.8%。
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| 关 键 词： | Vilsmeier反应 喹唑啉 合成 |
Vilsmeier Reactions of 2-Phenylquinazoline-4-one |
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| ZHAO Chun-hong,LI Shen-qing,WU Bin,LIU Jin-hao,DONG Dan-dan,LIU Gang.Vilsmeier Reactions of 2-Phenylquinazoline-4-one[J].GuangZhou Chemical Industry and Technology,2011(3):73-75. |
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| Authors: | ZHAO Chun-hong LI Shen-qing WU Bin LIU Jin-hao DONG Dan-dan LIU Gang |
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| Affiliation: | 1(1 School of Chemistry and Materials Science,Ludong University,Shandong Yantai 264025;2 Huantai Second Middle School,Shandong Zibo 256400,China) |
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| Abstract: | 2-phenyl-quinazoline-4-one was synthesized with 2-aminobenzoic acid,benzoic anhydride and acetic acid via a green synthesis method,and its Vilsmeier reactions were determined.The structure of the title compound was characterized by IR.The effect for the Vilsmeier reaction of the reaction time,reaction temperature and the proportions of raw material were discussed.Results showed the highest yield approach 67.8% when mol ratio of POCl3 to 2-phenyl-quinazoline-4-one was 1.5:1 in 80~90 ℃ and the reaction time was 4h. |
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| Keywords: | Vilsmeier reaction quinazoline synthesis |
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