红景天苷缓释微胶囊的制备及体外释放特性研究

目的:制备红景天苷微胶囊,测定其包封率,并考察其体外释药特性。方法:以生物相容性良好的壳聚糖和海藻酸钠为囊壁材料,红景天苷药物微粒为囊芯,采用静电吸引层层纳米自组装技术(LBL法)制备红景天苷微胶囊。结果:制备的微胶囊包封率较高,达到78.02±0.72%;不同包裹层数的微胶囊在体外释放速度不同。结论:用LBL法制备的红景天苷微胶囊具有较高的包封率和缓释特性,具有一定的应用前景。

Preparation and in vitro release of sustained salidroside microcapsule

Objective： Microcapsule for controlled release of Salidroside was prepared, and its encapsulation efficiency and drug release profile was determined in vitro. Method： The salidroside microcapsule was prepared using a novel coating technology based on the layer-by-layer（LBL） deposition of oppositely charged chitosan and alginate polyelectrolytes with good biocompatibility into microcrystal templates. Result： The entrapment effi ciency of the microcapsules was as high as 78.02±0.72%. The release rate of salidroside decreased as the bilayers increased in vitro. Conclusion： The microcapsule prepared by LBL deposition has high entrapment effi ciency and is characterized with slow drug release, which has potential for future application.