| 芹菜素对体外培养软骨肉瘤细胞增殖的抑制作用 |
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| 引用本文： | 李杰文,黄文武,邝桂星,黎毓光.芹菜素对体外培养软骨肉瘤细胞增殖的抑制作用[J].解剖学研究,2013(3):176-178. |
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| 作者姓名： | 李杰文 黄文武 邝桂星 黎毓光 |
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| 作者单位： | 番禺区中心医院;广州市番禺区市桥医院骨科;广州市番禺区南村医院检验科 |
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| 基金项目： | 广东省中医药局科技计划项目(20121017) |
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| 摘 要： | 目的探讨芹菜素对体外培养软骨肉瘤细胞株的作用。方法采用细胞培养技术,分别用0、20、40、80μmol/L芹菜素加入到培养的软骨肉瘤细胞株中,分别在培养24、48、72 h后,通过光学显微镜观察软骨肉瘤细胞株的形态学变化,采用四唑盐(MTT)比色法观察软骨肉瘤细胞株的生长情况。结果 40及80μmol/L芹菜素对软骨肉瘤的生长呈剂量和时间依赖性抑制。结论芹菜素有一定的抗软骨肉瘤活性,抑制软骨肉瘤细胞体外生长。
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| 关 键 词： | 软骨肉瘤 芹菜素 细胞增殖 |
Inhibitory effect of apigenin on chondrosarcoma cell lines Growth and proliferation |
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| LI Jie-wen,HUANG Wen-wu,Kuang Gui-xing,LI Yu-guang.Inhibitory effect of apigenin on chondrosarcoma cell lines Growth and proliferation[J].Anatomy Research,2013(3):176-178. |
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| Authors: | LI Jie-wen HUANG Wen-wu Kuang Gui-xing LI Yu-guang |
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| Affiliation: | . Central hospital of Panyu Disirict , Guangzhou 511400, China |
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| Abstract: | Objective To investigate the inhibitory effect and potential mechanisms of apigenin on chondrosarcoma cell.Methods Chondrosarcoma cells were treated by apigenin with various concentrations(20,40,80 μmol / L).Cell proliferation was measured by MTT assay on 24,48 and 72 h.Results Apigenin inhibited the growth and proliferation of chondrosarcoma cells in a dose-dependent and time-dependent manner.Inhibition of growth was observed at the concentration of 40 and 80 μmol / L.Conclusion The results demonstrate that apigenin has potent inhibitory action on chondrosarcoma cell growth and proliferation |
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| Keywords: | Apigenin Chondrosarcoma Cell proliferation |
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