Identification,characterization, and biological relevance of prostate cancer stem cells from clinical specimens |
| |
| Affiliation: | Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267-0056, USA;Department of Surgery, Division of Urology, Washington University School of Medicine, 4960 Children''s Place, 2nd Floor Wohl Hospital, Box 8242, St. Louis, MO 63110 |
| |
| Abstract: | Cancer stem cells (CSCs) are a reservoir of tumor cells that exhibit the properties of self-renewal and the ability to re-establish the heterogeneous cell population of a tumor. They appear therapy-resistant and may be the underlying cause of recurrent disease. Using prostate as a model, this review presents the CSC hypothesis and discusses the role of the androgen receptor in CSCs, the methods used for isolating CSCs, and the therapeutic challenges CSCs have for cancer therapy. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
