TTF-1在非小细胞肺癌中的表达及意义

目的探讨甲状腺转录因子-1（TTF-1）在非小细胞肺癌（NSCLC）组织中的表达及临床意义。方法采用免疫组化（SP法）对75例非小细胞肺癌（其中肺腺癌36例,肺鳞癌39例）组织中TTF-1的表达进行检测,以其正常癌旁组织作为对照,分析TTF-1在肺腺癌与鳞癌鉴别诊断中的意义,及其表达与患者临床病理特征及预后的关系。结果 TTF-1在肺腺癌中的阳性表达率为83.3%（30/36）,在肺鳞癌中的阳性表达率为7.69%（3/39）,差异有统计学意义（P〈0.05）;TTF-1的表达与患者性别、年龄、淋巴转移、肿瘤大小和肿瘤TNM分期等临床病理特征无关（P〉0.05）。Kaplan-Meier分析显示,肺腺癌阳性组患者的中位生存时间为30个月,明显高于阴性组患者的中位生存时间7.5个月,差异具有统计学意义（P〈0.05）;肺鳞癌阳性组患者的中位生存时间为29个月,阴性组为48个月,差异无统计学意义（P〉0.05）。结论检测TTF-1对非小细胞肺癌不同组织学类型的诊断、鉴别诊断具有一定的实用价值,其过高表达有可能作为肺腺癌预后良好的评估指标。

Expression and Clinical Significance of TTF-1 in Non-small Cell Lung Cancer

Objective To explore the expression and Clinical significance of TTF-1 in NSCLC tissues.Methods Immunohistochemistry（SP method）was used to detect the expression of TTF-1 in 75 cases of NSCLC tissues（including 36 cases of adenocarcinoma and 39 cases of squamous cell carcinoma）,with its normal carcinoma tissue adjacent to reference.The value of TTF-1 in the identification of adenocarcinoma and squamous cell carcinoma was explored.And the relationships between TTF-1 expression and clinicopathologic characteristics and prognosis in non-small cell lung cancers were analyzed.Results The positive expression rate of TTF-1 in adenocarcinoma tissues（30/36,83.3%） was significantly higher than that in squamous cell carcinoma tissues（3/39,7.69%）（P＆lt; 0.05）.And the expression of TTF-1 is unrelated to clinical and pathologic data such as patients’genders,ages,TNM stages,tumor size and lymph nodes metastasis（P＆gt;0.05）.Moreover,univariate prognostic factor analyzed by Kaplan-Meier method indicated that in the median survival time for adenocarcinoma with positively expression of TTF-1 was significantly longer than that of patients with negatively expression of TTF-1（P＆lt;0.05）.However,in squamous cell carcinoma,it doesn’t seem like it has a clearly meaning.Conclusion TTF-1 is involved in the development of lung cancer.The detection of expression of TTF-1 can be used for the diagnosis and identification of adenocarcinoma and squamous cell carcinoma.It might he a potentially valuable indicator to predict the prognosis of patients in NSCLC.