视神经脊髓型多发性硬化临床特点19例分析

目的分析视神经脊髓型多发性硬化（OSMS）患者的临床特征。方法收集19例符合Kira诊断标准OSMS患者的临床资料，并结合实验室检查进行分析。结果和结论19例OSMS患者在发病年龄、病程、起病症状、MRI检查、诱发电位、脑脊液寡克隆区带及治疗等方面与国外报道基本一致。但是本研究OSMS患者未见脑脊液淋巴细胞异常增多（pleocytosis），患者脑脊液蛋白亦低于国外报道，OSMS在不同类型MS中构成比例偏低（18．62％）。

Clinical Features of Opticospinal Multiple Sclerosis:19 Cases Report

ObjectiveTo investigate the clinical features of 19 patients with opticospinal multiple sclerosis(OSMS).Methods19 cases with OSMS according to Kira Criteria were collected(15 women).Their clinical features were analyzed in combination with the laboratory examination.Results and ConclusionThere was no significant difference in the aspects of age of onset,disease duration,initial symptoms,MRI finding,evoked potential,immunological test of cerebrospinal fluid(CSF),between literatures reported elsewhere and ours. However,in our study,the OSMS patients did not show CSF pleocytosis associated with a decreased protein levels.The proportion of OSMS in all the types of MS seemed to be lower(18.66%).