Clonal structural chromosome aberrations in fibrous dysplasia |
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Authors: | Fredrik Mertens Auxilium Albert Sverre Heim Johan Lindholm Otte Brosj Felix Mitelman Nils Mandahl |
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Affiliation: | Fredrik Mertens,Auxilium Albert,Sverre Heim,Johan Lindholm,Otte Brosjö,Felix Mitelman,Nils Mandahl |
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Abstract: | Cytogenetic analysis of short-term cultures from a case of monostotic fibrous dysplasia in a 14-year-old girl revealed multiple clonal structural rearrangements with evidence of clonal evolution. The karyotype was 46,XX,del(3)(q27),add(10)(q22), add(12)(p13)/46,idem,t(3;8)(p21;q13),add(10)(q26),der(15)del(15)(q15q22)ins(15;?)(q15;?)/46,idem,-X, + 2,t(3;8),add(10),der(15). The finding of clonal structural aberrations suggests that fibrous dysplasia is a neoplastic lesion which develops as the result of somatic mutations. |
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