| 鹦鹉热衣原体基因工程亚单位疫苗免疫羊抗体产生动力曲线 |
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| 引用本文： | 李岩伟,杨凤宝,宋立华,马桂花,朱虹,端青.鹦鹉热衣原体基因工程亚单位疫苗免疫羊抗体产生动力曲线[J].中国人兽共患病杂志,2010,26(9):835-836,839. |
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| 作者姓名： | 李岩伟 杨凤宝 宋立华 马桂花 朱虹 端青 |
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| 作者单位： | 李岩伟,宋立华,朱虹,端青(军事医学科学院微生物流行病研究所病原微生物生物安全国家重点实验室,北京,100071);杨凤宝(宁夏回族自治区盐池县滩羊选育场);马桂花(宁夏回族自治区盐池县动物疾病预防控制中心) |
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| 基金项目： | 艾滋病和病毒性肝炎等重大传染病防治 |
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| 摘 要： | 目的观察鹦鹉热衣原体基因工程亚单位疫苗免疫羊后产生的动力学曲线。方法用不同剂量鹦鹉热衣原体主要外膜蛋白基因工程亚单位疫苗免疫绵羊,免疫前及免疫后不同时间采血检测抗体情况,观察绵羊抗体的产生和变化水平。结果免疫剂量为0.5mg/只颈部肌肉多点注射,具有良好的免疫效果。结论鹦鹉热衣原体基因工程亚单位疫苗免疫剂量为0.5mg/只颈部肌肉多点注射,在绵羊整个妊娠期内具有保护作用。
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| 关 键 词： | 衣原体亚单位疫苗 免疫 动力曲线 |
Kinetics curve of antibody responses in ewes immunized with subunit vaccine of genetically engineered Chlamydia psittaci |
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| LI Yan-wei,YANG Feng-bao,SONG Li-hua,MA Gui-hua,ZHU Hong,DUAN Qing.Kinetics curve of antibody responses in ewes immunized with subunit vaccine of genetically engineered Chlamydia psittaci[J].Chinese Journal of Zoonoses,2010,26(9):835-836,839. |
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| Authors: | LI Yan-wei YANG Feng-bao SONG Li-hua MA Gui-hua ZHU Hong DUAN Qing |
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| Affiliation: | (State Key Laboratory of Pathogen and Biosecurity,Institute of Microbiology and Epidemiology,Academy of Military Medical Science,Beijing 100071,China) |
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| Abstract: | This study analyzed antibody responses in ewes vaccinated with three different doses of major outer-membrane protein subunit vaccine from genetically engineered Chlamydia psittaci.Sera of ewes were detected before vaccination and at different times post-vaccination.Experimental results indicated that multilocus intramuscular injection in the neck region with dose of 0.5 mg per ewe could stimulate good immune response. |
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| Keywords: | chlamydial subunit vaccine immune kinetic curve |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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