| 毛梗稀莶抗生育活性成分的研究 |
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| 引用本文： | 董祥英,陈敏,荆伟,黄大宪,沈珊梅,李惠庭.毛梗稀莶抗生育活性成分的研究[J].药学学报,1989,24(11):833-836. |
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| 作者姓名： | 董祥英 陈敏 荆伟 黄大宪 沈珊梅 李惠庭 |
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| 作者单位： | 国家医药管理局上海医药工业研究院,上海200040 |
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| 摘 要： | 自菊科植物毛梗豨莶Siegesbeckia glabrescens Mak的全草中分得一个新的二萜甙,命名为豨莶新甙(neodarutoside),经光谱(IR,1 HNMR,13 CNMR和MS)分析,确定结构为(I);同时分得的二萜有豨莶精醇(darutigenol,Ⅳ)和豨莶甙(d&rutoside,Ⅴ)。豨莶甙(Ⅴ)在20～40 mg/kg剂量时,对大鼠有明显抗早孕作用。
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| 关 键 词： | 毛梗豨莶 豨莶新甙 豨莶精醇 豨莶甙 抗生育剂 |
| 收稿时间： | 1988-09-19 |
STUDIES ON ANTIFERTILITY CONSTITUENTS OF SIEGESBECKIA GLABRESCENS MAK |
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| XY Dong,M Chen,W Jin. DX Huang,SM Shen and HT Li.STUDIES ON ANTIFERTILITY CONSTITUENTS OF SIEGESBECKIA GLABRESCENS MAK[J].Acta Pharmaceutica Sinica,1989,24(11):833-836. |
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| Authors: | XY Dong M Chen W Jin DX Huang SM Shen and HT Li |
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| Abstract: | Three diterpenes including a new compound were isolated from the whole plant of Siegesbeckia glabrescens Mak. The new one was named as neodarutoside and its structure was elucidated as ent-3 alpha, 15,16-trihydroxy pimarane 3,15-bis-(beta-glucopyranoside) based on the spectral evidence and chemical transformation. The other two were darutigenol and darutoside. Darutoside possesses the activity of termination of early pregnancy in experimental rats at a dosage of 20-40 mg/kg. |
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| Keywords: | Siegesbeckia glabrescens Neodarutoside Darutigenol Darutoside Antifertility agent |
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