Natural infection of vertebrate hosts by different lineages of Buggy Creek virus (family Togaviridae, genus Alphavirus) |
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| Authors: | Charles R Brown Amy T Moore Valerie A O’Brien Abinash Padhi Sarah A Knutie Ginger R Young Nicholas Komar |
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| Affiliation: | (1) Department of Biological Sciences, University of Tulsa, Tulsa, OK 74104, USA;(2) Department of Biology, Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, PA 16802, USA;(3) Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, P.O. Box 2087, Fort Collins, CO 80522, USA;(4) Present address: Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078, USA;(5) Present address: Department of Biology, University of Utah, Salt Lake City, UT 84112, USA |
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| Abstract: | Buggy Creek virus (BCRV; family Togaviridae, genus Alphavirus) is an arbovirus transmitted by the ectoparasitic swallow bug (Hemiptera: Cimicidae: Oeciacus vicarius) to cliff swallows (Petrochelidon pyrrhonota) and house sparrows (Passer domesticus). BCRV occurs in two lineages (A and B) that are sympatric in bird nesting colonies in the central Great Plains, USA. Previous
work on lineages isolated exclusively from swallow bugs suggested that lineage A relies on amplification by avian hosts, in
contrast to lineage B, which is maintained mostly among bugs. We report the first data on the BCRV lineages isolated from
vertebrate hosts under natural conditions. Lineage A was overrepresented among isolates from nestling house sparrows, relative
to the proportions of the two lineages found in unfed bug vectors at the same site at the start of the summer transmission
season. Haplotype diversity of each lineage was higher in bugs than in sparrows, indicating reduced genetic diversity of virus
amplified in the vertebrate host. BCRV appears to have diverged into two lineages based on different modes of transmission. |
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