| 丁螺环酮与地西泮治疗焦虑症双盲比较 |
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| 引用本文： | 陈佐明,胡宪章,张迎黎,张建宏.丁螺环酮与地西泮治疗焦虑症双盲比较[J].中国新药与临床杂志,1998(2). |
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| 作者姓名： | 陈佐明 胡宪章 张迎黎 张建宏 |
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| 作者单位： | 河南省精神病医院 |
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| 摘 要： | 目的：比较丁螺环酮与地西泮治疗焦虑症的疗效及不良反应。方法：采用随机双盲对照研究的方法，分为丁螺环酮组２３例（男性１１例，女性１２例；年龄３８±ｓ１３ａ），予丁螺环酮１５ｍｇ，ｐｏ，ｔｉｄ；４ｗｋ为一个疗程。地西泮组２２例（男性９例，女性１３例；年龄４１±１３ａ），予地西泮７．５ｍｇ，ｐｏ，ｔｉｄ；４ｗｋ为一个疗程。结果：丁螺环酮组有效率为８７％，地西泮组９１％，２组比较Ｒｉｄｉｔ分析Ｐ＞０．０５。药物不良反应发生率地西泮组高于丁螺环酮组，但反应轻微不影响治疗。结论：丁螺环酮与地西泮疗效相同，不良反应少。
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| 关 键 词： | 丁螺环酮 地西泮 焦虑症 双盲法 |
Buspirone vs diazepam in treating anxiety disorders in a double_blind study |
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| CHEN Zuo_Ming,HU Xian_Zhang,ZHANG Ying_Li,ZHANG Jian_Hong.Buspirone vs diazepam in treating anxiety disorders in a double_blind study[J].Chinese Journal of New Drugs and Clinical Remedies,1998(2). |
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| Authors: | CHEN Zuo_Ming HU Xian_Zhang ZHANG Ying_Li ZHANG Jian_Hong |
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| Abstract: | AIM: To compare the effects and adverse reactions of buspirone and diazepam in treating anxiety disorders. METHODS: Forty_five anxious patients were divided randomly into 2 groups: 23 patients (M 11, F 12, age 38±s 13 a) were treated with buspirone, 15 mg, po, tid for 4 wk; 22 patients (M 9, F 13, age 41±11 a) were treated with diazepam, 7.5 mg, po, tid for 4 wk. RESULTS: The total clinical effective rates were 87% for buspirone, and 90% for diazepam (P>0.05). The adverse reactions in diazepam group was higher than in buspirone group. But this did not hinder the treatment because the adverse reactions were mild. CONCLUSION: Buspirone showed the same effects but less adverse reactions than diazepam. |
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| Keywords: | buspirone diazepam anxiety disorders double_blind method |
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