ACEI治疗中老年高血压的疗效观察与分析

目的探讨血管紧张素转换酶抑制剂（ACEI）类药物治疗中老年高血压的临床特点及疗效。方法将确诊为原发性高血压患者118例，观察患者使用ACEI类药物治疗前后的血压、肾脏功能、心功能、代谢功能变化情况。结果ACEI治疗后，患者收缩压和舒张压（P〈0．01），24小时尿蛋白定量（P〈0．05），左室舒张末容积和左室收缩末容积（P〈0．05和P〈0．01）明显降低，左室射血分数和心输出量明显增加（P〈0．05），差异有统计学意义。治疗前后患者的血钾、血肌酐、血糖、血脂无明显变化。结论ACEI在有效降血压的同时，保护心脏、肾脏功能，对糖、脂代谢无影响，是临床理想的降压药物。

ACEI for hypertension in middle-aged and elderly patients

Objective To explore the clinical efficacy of angiotensin-converting enzyme inhibitors （A- CEIs） for hypertension in middle-aged and elderly patients. Methods One hundred and eighteen patients with primary hypertension were treated with ACEI. Changes in blood pressure, renal function, cardiac function, and metabolic function were observed after treatment. Results Systolic and diastolic pressure （P〈0.01）, 24-hour urinary protein （P〈0.05）, left ventricular end-diastolic volume （P〈0.05）, and left ventricular end-systolic vol- ume （P〈0.01） declined obviously, whereas left ventricular ejection fraction and cardiac output increased markedly （P〈0.05）. All the differences were statistically significant. Meanwhile, no marked changes in serum potassium and creatinine and blood sugar and lipids were observed after treatment. Conclusions ACEIs effec- tively reduce blood pressure and protect cardiac and renal function, but have no effect on sugar and lipid metabolism. ACEIs are an ideal class of antihypertensive agents.