Cardioprotective effects of cerebrolysin on the lesion severity and inflammatory factors in a rat model of isoproterenol-induced myocardial injury |
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| Affiliation: | 1. Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran;2. Department of Physiology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran;3. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran;4. Department of Pathology, Kashan University of Medical Sciences, Kashan, Iran;1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Egypt;2. Laboratory for Vascular Translational Sciences, INSERM U1148, X. Bichat Hospital, University Paris XIII, France;1. Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, ?ód?, Poland;2. Department of General and Colorectal Surgery, Faculty of Military Medicine, Medical University of Lodz, ?ód?, Poland;3. Department of Gastroenterology, Faculty of Military Medicine, Medical University of Lodz, ?ód?, Poland;1. Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland;2. Department of Paediatrics in Bytom, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland;1. Department of Internal Medicine and Metabolic Diseases, School of Health Sciences, Medical University of Silesia, Katowice, Poland;2. Department of Gastroenterology and Hepatology, School of Medicine, Medical University of Silesia, Katowice, Poland;3. Health Promotion and Obesity Management Unit, Department of Pathophysiology, School of Medicine, Medical University of Silesia, Katowice, Poland;4. Department of Biophysics, School of Medicine, Medical University of Silesia, Katowice, Poland;5. Department of Internal Medicine, Autoimmune and Metabolic Diseases, School of Medicine, Medical University of Silesia, Katowice, Poland |
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| Abstract: | BackgroundMyocardial injury (MI) is an important heart condition and a major cause of morbidity and mortality worldwide. The current study was designed to investigate the cardioprotective effects of cerebrolysin (CLY) on the lesion severity and inflammatory factors in male rats using isoproterenol (ISO)-induced MI model.MethodsMI in rats was induced by injecting ISO (100 mg/kg) subcutaneously (sc) on the first 2 days. Then, CLY (5 ml/kg) was injected intraperitoneally (ip) post-treatment for 7 days. On the 3rd day, creatine phosphokinase (CK-MB) and cardiac troponin I (cTnI) levels in serum and, on the 10th day, the TNF-α and IL6 levels in serum and heart tissue were measured by enzyme-linked immunosorbent assay (ELISA). Finally, the heart of each rat was dissected out and stained for histopathological examination.ResultsOn the 3rd day, the serum CK-MB and cTnI levels in the ISO and CLY + ISO groups were significantly increased compared with that in the control and CLY + Sal groups. One week after the induction of MI, ISO administration showed a significant increase in the serum level of TNF-α in the ISO group compared with that in the control and CLY + Sal groups. Also, our findings showed only a moderate reduction in inflammatory cell infiltration and extent of edema following CLY treatment in the CLY + ISO group. Also, CLY induced vascular proliferation in the heart tissue.ConclusionsWe conclude that the severity of pathological changes induced by ISO in MI (e.g. inflammation and edema) can be limited by CLY treatment. |
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| Keywords: | Isoproterenol Cerebrolysin Inflammatory factor Myocardial injury Rat |
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