| ALTERATION OF CHOLESTEROL SULFATE IN HUMAN SERA DURING THE COURSE OF PREGNANCY |
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| 作者姓名： | 林蓓 张淑兰 岩森正男 |
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| 作者单位： | Department of Gynecology and Obstetrics，the Second Affiliated Hospital，China Medical University，Shenyang 110004，China，Department of Gynecology and Obstetrics，the Second Affiliated Hospital，China Medical University，Shenyang 110004，China，Department of Biochemistry，Faculty of Science and Technology，Kinki University，Higashiosaka，Osaka 577 - 8502，Japan |
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| 摘 要： | Objective To determine the concentrations of cholesterol sulfate ( CS) in human sera and pla-cental villi during the course of pregnancy. And to analyze its inhibitory activity on thrombin and further characterize the functional significance of CS. Methods The concentrations of CS were determined by thin-layer chromatog-raphy (TLC) on 60 cases of normal pregnant women and 30 cases of normal placental villi. The effect of CS in human sera on the activity of thrombin was analyzed. Results The concentrations of CS in human sera gradually increased from the first to third trimester of gestation with a correlation coefficient of 0. 69, and a correlation between the concentration of CS and weeks of gestation (P <0. 01). CS was also contained in the placental villi, and its concentrations at the second and third trimester of gestations were 4. 7 and 6. 2-fold of that at the first trimester of gestation. CS inhibited the activity of thrombin. Conclusion Placental CS is one of the sources of CS in the serum , pr
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| 关 键 词： | TLC 胆固醇 硫酸盐 血清 怀孕 凝血酶 胎盘绒毛 女性 |
ALTERATION OF CHOLESTEROL SULFATE IN HUMAN SERA DURING THE COURSE OF PREGNANCY |
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| LIN Bei,ZHANG Shu-Ian.ALTERATION OF CHOLESTEROL SULFATE IN HUMAN SERA DURING THE COURSE OF PREGNANCY[J].Journal of Shanghai Second Medical University(Foreign Language Edition),2004,16(2):96-100. |
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| Authors: | LIN Bei ZHANG Shu-Ian |
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| Affiliation: | LIN Bei,ZHANG Shu-Ian
Department of Gynecology and Obstetrics,the Second Affiliated Hospital,China Medical University,Shenyang
110004,China
Iwamori Masao
Department of Biochemistry,Faculty of Science and Technology,Kinki University,Higashiosaka,Osaka 577 - 8502,Japan |
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| Abstract: | Objective To determine the concentrations of cholesterol sulfate ( CS) in human sera and pla-cental villi during the course of pregnancy. And to analyze its inhibitory activity on thrombin and further characterize the functional significance of CS. Methods The concentrations of CS were determined by thin-layer chromatog-raphy (TLC) on 60 cases of normal pregnant women and 30 cases of normal placental villi. The effect of CS in human sera on the activity of thrombin was analyzed. Results The concentrations of CS in human sera gradually increased from the first to third trimester of gestation with a correlation coefficient of 0. 69, and a correlation between the concentration of CS and weeks of gestation (P <0. 01). CS was also contained in the placental villi, and its concentrations at the second and third trimester of gestations were 4. 7 and 6. 2-fold of that at the first trimester of gestation. CS inhibited the activity of thrombin. Conclusion Placental CS is one of the sources of CS in the serum , probably by shedding. From the observation that CS inhibited the activity of thrombin, the increased expression of CS may play an important role in the regulation of blood coagulation during the course of pregnancy. |
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| Keywords: | cholesterol sulfate pregnancy placental villi thrombin |
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