血清IL-10水平在老年鼻咽癌诊治中的应用价值

目的探讨血清白细胞介素-10（IL-10）水平的检测在鼻咽癌诊治中的临床应用价值。方法采用ELISA法，检测53例老年鼻咽癌患者和20例正常人血清IL-10水平，对患者的临床生物学行为及预后进行比较，并采用Cox方法进行生存分析。结果鼻咽癌患者血清IL-10水平明显高于正常对照组；T1患者的血清IL—10水平明显低于T2、T3及T4患者的血清IL-10水平，差异有统计学意义；有颈淋巴结转移患者血清IL-10水平稍高于无淋巴结转移患者，但差异无统计学意义；有远处转移患者血清IL-10水平稍高于无远处转移患者，但差异无统计学意义；早期鼻咽癌（Ⅰ期＋Ⅱ期）患者血清IL-10水平明显低于中晚期鼻咽癌（Ⅲ期＋Ⅳ期）患者血清IL-10水平，差异有统计学意义。cox生存分析结果显示，临床分期和远处转移是影响鼻咽癌患者生存率的危险因素。结论血清IL-10水平检测在鼻咽癌的诊断、分期和预后判定中具有-定的临床应用价值。

Clinical value of serum interleukin-lO levels in nasopharyngeal carcinoma

Objective To evaluate the clinical significance of detecting of serum interleukin-10 （IL-10） levels in nas- opharyngeal carcinoma （NPC） patients. Methods Serum IL-10 level was detected by ELISA in 53 patients with NPC and in the 20 subjects in the control group, and the biological behavior and clinical prognosis of patients were compared, and survival analysis using Cox regression. Results Serum IL-10 level in NPC was significantly higher than that in the control group （P〈0.05）. Serum IL-10 level in T1 patients was significantly lower than that in the patients in T2, T3 and T4 （P〈0.05）. Serum IL-10 level in patients with lymph node metastases or distant metastases was higher than that in patients without lymph node metastases or distant metastases, bu no statistical significance were observed. Serum IL-10 levels in stage Ⅰ and Ⅱ patients were significantly lower than that in the patients in stage Ⅲ and Ⅳ . The survival analysis by Cox regression showed that clinical stage and distant metastases had significantly association with survival rate. Conclusions Detection of serum IL-10 level is of significance in diagnosing, staging, and evaluation the outcome for NPC patients, and it is worthy of further study.