Ge-132对荷瘤小鼠NK细胞活性及红细胞免疫功能的影响

为探讨Ｇｅ－１３２抗癌作用机制，进行了Ｇｅ－１３２对荷瘤小鼠脾脏ＮＫ细胞活性和红细胞免疫粘附功能影响的体内实验研究，结果表明，Ｇｅ－１３２对小鼠移植瘤（Ｓ１８０）的生长具有显著的抑制效应，抑制率达５５％，荷瘤小鼠脾脏ＮＫ细胞活性明显低于正常对照组，Ｇｅ－１３２能使其恢复；荷瘤小鼠ＲＢＣ－Ｃ３ｂ受体花环率和肿瘤ＲＢＣ花环率明显低于正常对照组（Ｐ〈０．０１），ＲＢＣ－ＩＣ花环率则高于正常对照组（Ｐ〈０

The Effect of Ge-132 on NK Cell Activity and Red Cell Immune Function in Tumor-Bearing Mice

? In the present study, the in vivo effect of Ge 132 on NK cell activity and red cell immune function in tumor bearing mice was observed. The results showed that Ge 132 could significantly inhibit the growth of the tumor in the tumor bearing mice. the activity of NK cells and the levels of RBC C 3b receptor rosette forming rate(RBC C 3bRR) and RBC tumor rosette forming rate(RBC TR) in tumor bearing mice were significantly lower than those in normal control group ( P <0.01). However, the RBC immune complex rosette forming rate(RBC ICR) was higher in tumor bearing mice than that in normal control group ( P <0.01). Ge 132 could enhance NK activity and increase RC 3bRR and RBC TR and decrease RICR of tumor bearing mice compared with tumor control group. The results indicated that Ge 132 could significantly enhance the activity of NK cells and the red cell immune function in tumor bearing mice. The anti cancer effect of Ge 132 may be mediated by regulating the immune functions in tumor subjects.