| 升麻研究进展及其质量标志物的预测分析 |
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| 引用本文： | 黄广欣,龚苏晓,许浚,姚奕,张铁军,刘昌孝.升麻研究进展及其质量标志物的预测分析[J].中草药,2020,51(10):2651-2660. |
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| 作者姓名： | 黄广欣 龚苏晓 许浚 姚奕 张铁军 刘昌孝 |
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| 作者单位： | 天津中医药大学, 天津 300193;中药现代制剂与质量控制技术国家地方联合工程实验室, 天津 300301;天津市中药质量标志物重点实验室, 天津 300301;中药现代制剂与质量控制技术国家地方联合工程实验室, 天津 300301;天津市中药质量标志物重点实验室, 天津 300301;释药技术与药物代谢动力学国家重点实验室(天津药物研究院), 天津 300301 |
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| 基金项目： | 国家自然科学基金资助项目（81830111）;国家自然科学基金资助项目（81703802）;"中医药现代化研究"重点专项（2019YFC1711200）资助项目 |
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| 摘 要： | 升麻始载于《神农本草经》,列为上品,是我国传统发散风热类中药。近年来国内外学者对升麻各方面研究逐渐深入,其新的化学成分与药理作用不断被发现。通过查阅文献,在对其化学成分与药理作用进行总结的基础上,根据质量标志物的定义,从生源途径、药效、传统药性、不同配伍中显效成分几个方面对升麻的质量标志物进行预测,为升麻质量评价研究提供科学依据。
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| 关 键 词： | 升麻 化学成分 药理作用 质量评价 质量标志物 |
| 收稿时间： | 2020/2/22 0:00:00 |
Research progress of Cimicifugae Rhizoma and prediction analysis on Q-marker |
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| HUANG Guang-xin,GONG Su-xiao,XU Jun,YAO Yi,ZHANG Tie-jun,LIU Chang-xiao.Research progress of Cimicifugae Rhizoma and prediction analysis on Q-marker[J].Chinese Traditional and Herbal Drugs,2020,51(10):2651-2660. |
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| Authors: | HUANG Guang-xin GONG Su-xiao XU Jun YAO Yi ZHANG Tie-jun LIU Chang-xiao |
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| Affiliation: | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine, Tianjin 300301, China;Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin 300301, China;National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine, Tianjin 300301, China;Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin 300301, China;State Key Laboratory of Drug Delivery and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300301, China |
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| Abstract: | Cimicifugae Rhizoma is contained in the "Shen Nong''s Herbal Classic" and listed as the top grade. It is a traditional Chinese medicine for divergent wind and heat. In recent years, scholars have gradually deepened their research on various aspects of Cimicifugae Rhizoma, and its new chemical components and pharmacological effects have been discovered. Based on the review of the literature, the summary of its chemical composition and pharmacological effects, according to the definition of Q-marker, from the aspects of the source route, drug efficacy, traditional drug properties, and the significant components in different compatibility, the Q-marker of Cimicifugae Rhizoma is predicted, in order to provide a scientific basis for the quality evaluation of Cimicifugae Rhizoma. |
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| Keywords: | Cimicifugae Rhizoma chemical compositions pharmacological effects quality evaluation Q-marker |
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