中药有效成分抗肿瘤活性及作用机制研究进展

中医药已有2 000多年的历史，并已获得广泛的临床应用，随着诊疗水平的提高，中药在延长癌症患者生存期、提高其生活质量等方面的作用得到了越来越多的关注和认可。中药抗肿瘤的活性与机制有多途径、多靶点、多通路的特点，如抑制肿瘤细胞增殖，促进肿瘤细胞凋亡，抑制肿瘤细胞侵袭、转移，调节肿瘤微环境，抗肿瘤血管生成，逆转药物耐药等。对目前抗肿瘤有明确疗效的中药有效成分作用机制进行综述，以期为中医药抗肿瘤研究提供一定的思路和理论依据。

Review of anti-tumor activity and mechanism of Chinese materia medica active ingredients

Traditional Chinese medicine has a history of more than 2 000 years with wide application in clinical practice. With the progress of diagnosis and treatment, the role of Chinese materia medica in extending the survival period of cancer patients and improving their quality of life has received increasing attention and recognition. The anti-tumor activity and mechanism of Chinese materia medica have the characteristics of multi-pathway, multi-target, and multi-pathway, such as inhibiting tumor cell proliferation, promoting tumor cell apoptosis, inhibiting tumor cell invasion and metastasis, regulating tumor microenvironment, anti-tumor angiogenesis, and reversing drug resistance. The mechanism of anti-tumor monomer in Chinese materia medica was reviewed in order to provide some ideas and theoretical basis for the anti-tumor research of traditional Chinese medicine.