小儿幽门螺杆菌感染伴消化性溃疡药物治疗研究

目的比较不同方案治疗小儿消化性溃疡的疗效和幽门螺杆菌(Hp)根除率。方法109例Hp感染伴消化性溃疡患儿分2组接受治疗;A组治疗方案为西米替丁15mg/(kg·d)、阿莫西林50mg/(kgod)、枸橼酸铋7～8mg/(kg·d)、甲硝唑15～20mg/(kg·d)疗程4周;B组为克拉霉素15mg/(kg·d)、洛赛克0.8mg/(kg·d)、阿莫西林50mg/(kg·d)疗程2周;停药4周后复查胃镜及Hp检测。结果①溃疡治愈率:A组85%;B组96%;②Hp根除率:A组72.2%;B组92.7%;③Hp根除者溃疡愈合率100%;未根除者愈合率47%;二者比较显著差异(P<0.01)。结论质子泵抑制剂奥美拉唑加二联抗生素治疗小儿Hp感染的消化性溃疡具有疗程短、疗效高、耐药少、依从性好等优点。

Treatment of Pediatric Peptic Ulcer with Helicobacter Pylori Infection

Objective To investigate the efficacy of different therapy in the management of peptic ulcer and the eradicative rate of helicobacter pylori(Hp).Methods Children who has peptic ulcer with helicobacter pylori infection were divided into two groups. Group A was treated with cimitidine 15mg/(kg·d) amoxicillin 50mg/(kg·d) + bismuth citrate 7～8mk/(kgod) + metronidzole 15～20mg/(kg·d) for 4 weeks;Group B was treated with clarithromycin 15mg/(kg·d) + omeperazole 0.Smg/(kg·d) + amoxicillin 50mg/(kg·d) for 2weeks. Results The rates of eradicate of peptic ulcer:group A 85% ,group B 96%. The rates of eradicate of Hp:group A 72.2% ,group B 92.7%.The difference between two groups were very significant. Conclusion Proton pump inhibitor(Ome)in combination with antibiotics therapy is more effective, less duration, well tolerated less resistant, with higher rate of eradication.