女贞养阴颗粒对美多巴为主抗震颤麻痹增效减毒作用的临床观察 |
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引用本文: | 胡学军,杨晓苏,杨旭光,周东阳,谭光波,伍大华,阳立.女贞养阴颗粒对美多巴为主抗震颤麻痹增效减毒作用的临床观察[J].中国中西医结合杂志,2003,23(11):811-814. |
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作者姓名: | 胡学军 杨晓苏 杨旭光 周东阳 谭光波 伍大华 阳立 |
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作者单位: | 1. 湖南省中医药研究院附属医院,长沙,410006 2. 中南大学湘雅医学院 |
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基金项目: | 湖南省中医药管理局资助项目(No.20328) |
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摘 要: | 目的:观察并评价女贞养阴颗粒对美多巴、安坦治疗震颤麻痹的增效与减毒作用。方法:采用随机双盲方法,对因服美多巴、安坦疗效衰减或出现明显毒副反应的震颤麻痹患者30例加服中药女贞养阴颗粒治疗,并与对照组(加服安慰剂)30例作对比观察。结果:治疗组和对照组的总有效率分别为86.7%和56.7%,证候总进步率分别为90.0%和56.7%,减毒总有效率分别为90.0%和43.3%,两组比较差异均有显著性(P<0.05或P<0.01);同时表明,女贞养阴颗粒对美多巴、安坦在消化系统、神经精神系统、心血管系统的不良反应有明显治疗作用。结论:初步认为女贞养阴颗粒对美多巴、安坦治疗震颤麻痹有明显的增效减毒作用。
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关 键 词: | 女贞养阴颗粒 美多巴 震颤麻痹 增效减毒作用 临床观察 |
修稿时间: | 2002年8月28日 |
Clinical Observation on the Efficacy Enhancing and Toxicity Attenuating Effect of Nuzhen Yangyin Granule to the Anti-Parkinsonism Therapy Mainly with Medopa |
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Authors: | HU Xue-jun YANG Xiao-su YANG Xu-guang |
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Abstract: | Objective: To observe and assess the efficacy enhancing and toxicity attenuating effect of Nuzhen Yangyin Granule (NYG) to the anti-parkinsonism (paralysis agitans) therapy with Medopa and Artane. Methods: Adopting the randomized double-blinded method, the effect of adding NYG to 30 patients with Parkinsonism in the treated group, who already received anti-Parkinsonism treatment but showing decreased response to Medopa and Artane and with obvious adverse reaction, was observed and controlled by 30 patients treated by adding placebo. Results: The total effective rate in the treated group and the control group was 86.7 % and 56.7% respectively, the total syndrome improving rate was 90 % and 56. 7 % respectively and the toxicity attenuating rate 90 % and 43.3 % respectively, comparison between the two groups showed significant difference (P<0.05 or P<0.01). NYG also showed markedly effective in reducing the adverse reactions of Medopa and Artane on digestive, neuro-psychiatric and cardiovascular system. Conclusion: NYG has obvious efficacy enhancing and toxicity attenuating effects caused by the anti-Parkinsonism treatment with Medopa and Artane. |
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Keywords: | Nuzhen Yangyin Granule paralysis agitans Medopa efficacy enhancing and toxic attenuating effect |
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