| 2-羟乙基吡啶的常压合成研究 |
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| 引用本文： | 杨海燕,闫晓红,徐文辉,李善清.2-羟乙基吡啶的常压合成研究[J].精细化工中间体,2012,42(4):25-28. |
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| 作者姓名： | 杨海燕 闫晓红 徐文辉 李善清 |
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| 作者单位： | 山东海洋精细化工重点实验室 山东省海洋化工科学研究院,山东 潍坊,262737 |
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| 摘 要： | 研究了以2-甲基吡啶和多聚甲醛常压催化合成2-羟乙基吡啶的方法。从反应类型和机理出发,分析了在反应过程中不同性质的催化剂的影响;然后根据推论,采用酸碱两类催化剂,并对其催化效果分析比较,发现碱性催化剂三乙胺,更有利于2-羟乙基吡啶合成;探讨了催化剂量、反应比例、反应时间等影响因素,得出了适宜的反应条件:n(2-甲基吡啶)∶n(甲醛)=5∶1,在三乙胺催化下,反应时间40 h,反应收率85.2%,产物纯度可达99.0%,水分低于1.0%。
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| 关 键 词： | 2-羟乙基吡啶 2-甲基吡啶 多聚甲醛 常压催化合成 |
Synthesis of 2-(2-Hydroxyethyl)pyridine Under Atmospheric Pressure |
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| YANG Hai-yan
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YAN Xiao-hong
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XU Wen-hui
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LI Shan-qing.Synthesis of 2-(2-Hydroxyethyl)pyridine Under Atmospheric Pressure[J].Fine Chemical Intermediates,2012,42(4):25-28. |
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| Authors: | YANG Hai-yan YAN Xiao-hong XU Wen-hui LI Shan-qing |
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| Affiliation: | (Shandong Ocean Chemical Industry Key Laboratory,Shandong Ocean Fine Chemical Industry Scientific Research Institute,Weifang 262737,China) |
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| Abstract: | The catalytic synthesis of 2-(2-hydroxyethyl)pyridine from 2-methyl pyridine and paraformaldehyde under atmospheric pressure was studied.Comparison of acid and basic catalysts showed that triethylamine was the most effective catalyst.The optimal reaction conditions were determined as following:the molar ratio of 2-methyl pyridine to paraformaldehyde was 5 to 1,the reaction time was 40 h.Under these conditions,the target product was prepared in 85.2% yield with a purity of 99%. |
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| Keywords: | 2-(2-hydroxyethyl)pyridine 2-picoline paraformaldehyde normal pressure catalytic reaction |
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