| 血、尿胱抑素C在糖尿病肾病早期检测中的应用价值 |
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| 引用本文： | 陈正徐,王莉,李曼.血、尿胱抑素C在糖尿病肾病早期检测中的应用价值[J].安徽医药,2011,15(10):1272-1273. |
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| 作者姓名： | 陈正徐 王莉 李曼 |
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| 作者单位： | 安徽省合肥市第二人民医院检验科,安徽,合肥,230011;安徽省合肥市第二人民医院检验科,安徽,合肥,230011;安徽省合肥市第二人民医院检验科,安徽,合肥,230011 |
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| 基金项目： | 合肥市科技局自然科学研究项目 |
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| 摘 要： | 目的探讨血、尿胱抑素C在监测糖尿病肾病早期肾损伤的临床应用价值。方法检测120例健康人员和65例糖尿病患者的血、尿胱抑素C、肌酐、微量白蛋白、α1-微球蛋白等指标,按微量白蛋白的检测结果将糖尿病患者分为正常、升高两组。结果血、尿胱抑素C在微量白蛋白正常、升高两组均升高(P<0.05),在糖尿病肾病早期检测中血、尿胱抑素C的诊断符合率分别为90.8%、96.9%。结论血、尿胱抑素C有较高的灵敏度和特异性,是糖尿病肾病早期肾损伤的敏感指标。
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| 关 键 词： | 胱抑素C 糖尿病肾病 微量白蛋白 α1-微球蛋白 |
Value of blood and urine cystatin C in diabetic nephropathy monitoring |
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| CHEN Zheng-xu,WANG Li,LI Man.Value of blood and urine cystatin C in diabetic nephropathy monitoring[J].Anhui Medical and Pharmaceutical Journal,2011,15(10):1272-1273. |
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| Authors: | CHEN Zheng-xu WANG Li LI Man |
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| Affiliation: | (Department of Clinical Laboratory,The Second People＇s Hospital of Hefei,Hefei 230011,China) |
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| Abstract: | Aim To observe the application effect of blood and urine cystatin C in diabetic nephropathy.Methods Detection of 120 healthy persons and 65 diabetic patients blood and urine cystatin C,creatinine,microalbumin,α1-microglobulin and other indicators was conducted.Based on results of microalbumin diabetic patients were divided into normal and abnormal groups.Results Blood and urine cystatin C in the normal and abnormal group were significantly higher（P0.05）.The diagnosis rate of blood and urine cystatin C were 90.8% and 96.9% in diabetic nephropathy.Conclusion Blood and urine cystatin C were sensitive and specific indicators for glomerular damage and renal tubular dysfunction in diabetic nephropathy. |
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| Keywords: | cystatin C DN MA α1-MG |
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