安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.

THE BENEFIT OF ANXIN PARTICAL IN TREATING PATIENTS UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION

Objective：To evaluate the effect of Anxin particle combined with thrombus aspiration on quality of life in patients with ST segment elevation myocardial infarction （STEMI） underwent primary percutaneous coronary intervention （PPCI）.Methods：160 STEMI patients underwent PPCI were randomized into two groups：Anxin group （AX）：Anxin particle （8.8g） was administrated before PPCI; Control group （CN）：The medications of patients in CN group were as same as AX group except for Anxin particle,including aspirin,clopidogrel,atorvastatin etc.MIDAS,SF-36 scores,bleeding events and thrombocytope nia were compared between two groups.Results：MIDAS and SF-36 scores were similar in two groups on admission and before discharge（P ＞0.05）.MIDAS and SF-36 scores in AX group were lower than control group at 180 days after discharge （P ＜0.05）.Nonetheless,when compared to admission,MIDAS and SF36 scores in both groups were reduced before discharge and 180 days after discharge （P ＜0.05）.Bleeding events and thrombocytopenia in both groups were similar（P ＞0.05）.Conclusion：The present study indicated that pretreatment with Anxin particle before PPCI,when combined with thrombus aspiration,could improve quality of life and not increase bleeding risk in patients with STEMI.