正常成人头CT灌注成像脑血流动力学定量研究

目的探讨多层螺旋CT灌注成像技术在正常人脑血流动力学研究中的应用。方法选择32例正常成人行常规头CT平扫后,再行多层螺旋CT灌注成像(MSCTPI)检查。在常规头CT平扫后,选取基底节及其相邻层面,经肘静脉团注对比剂,延迟5秒后开始连续50秒的电影扫描,重建的图象经CT灌注软件包进行后处理,获得脑血流量图、脑血容量图及平均通过时间图,测量所选脑内感兴趣区的脑血流量(CBF)值、脑血容量(CBV)值及平均通过时间(MTT)值,并进行定量分析。结果32例正常成人基底节区灌注均高于灰质区,而灰质区灌注高于白质区。基底节区CBF、CBV值分别为60.97±9.51 m l/100 g.m in1和2.06±0.40m l/100 g;灰质区分别为23.45±3.96 m l/100 g.m in和1.19±0.29 m l/100 g;白质区CBF、CBV值分别为15.01±3.42 m l/100 g.m in和0.94±0.14 m l/100 g。平均通过时间白质区最长,基底节区最短,基底节区、灰质区及白质区MTT值分别为2.18±0.45,3.01±1.07,4.44±0.85 s。结论MSCTPI技术为测量脑血流动力学指标提供了一种新的影像学方法。

Quantitative Study of the Cerebral Hemodynamics Using Multislice CT Perfusion Imaging in Normal Adult

Objective To explore the application of multislice CT perfusion imaging(MSCTPI) in normal adult cerebral hemodynamics.Methods Routine CT and MSCTPI were performed by selecting the basal ganglia slice and its adjacent slice in 32 normal adults.The contrast material was bolus injected through antecubital vein,while cine scans were performed for 50 seconds.These dynamic images were processed with the CT perfusion software package.Cerebral blood flow(CBF),cerebral blood volume(CBV) and mean transiting time(MTT) were measured within the specific regions of interest(ROI) of the brain,and quantitative analysis was performed.Results A gradient of perfusion between gray matter and white matter showed on MSCTPI in normal adults.The values of CBF and CBV were 60.97±9.51 ml/100 g ·min and 2.06±0.40 ml/100 g respectively in basal ganglia,15.01±3.42 ml/100 g·min and 0.94±0.14 ml/100 g wespectively in the white matter,and 23.45±3.96 ml/100 g·min and 1.19±0.29 ml/100 g respectively in gray matter.The longest MTT was in the white matter and the shortest was in the basal ganglia.MTT in the basal ganglia,gray matter and white matter were 2.18±0.45 s,3.01±1.07 s and 4.44±0.85 s respectively.Conclusion MSCTPI provided a new imaging method for measuring the cerebral hemodynamics.