| 灯盏花素原料药相关物质的分离和结构鉴定 |
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| 作者姓名： | 张赟华 董媛 肖琳婧 李忠琼 章文杰 张雯洁 |
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| 作者单位： | 1. 云南省食品药品检验所,云南 昆明,650011;2. 云南省科学技术中心,云南 昆明,650228 |
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| 摘 要： | 目的：分离、鉴定灯盏花素原料药中的主要相关物质。方法通过制备液相色谱分离灯盏花素原料药中4个主要相关物质，利用高分辨质谱、核磁共振方法进行结构鉴定。结果4个相关物质分别鉴定为6－羟基山柰酚－7－O －β－D －吡喃葡萄糖醛酸（1），灯盏花甲素（2）、野黄芩素（3）和芹菜素（4）。化合物1～4均为首次从灯盏花素原料中分离得到，且化合物1为灯盏花素原料药中新的相关物质。结论明确了灯盏花素原料药的物质基础，为其质量控制提供了科学依据。
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| 关 键 词： | 灯盏花素 相关物质 分离制备 结构鉴定 |
Isolation and identification of related substances from raw material of Breviscapine |
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| Authors: | ZHANG Yunhu DONG Yuan XIAO Linjing LI Zhongqiong ZHANG Wenjie and ZHANG Wenjie |
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| Affiliation: | 1.Yunnan Institute for Food and Drug Control,Kunming 650011,China,1.Yunnan Institute for Food and Drug Control,Kunming 650011,China,1.Yunnan Institute for Food and Drug Control,Kunming 650011,China,1.Yunnan Institute for Food and Drug Control,Kunming 650011,China,2.Yunnan Province science & technology exchange center,Kunming 650228,China and 1.Yunnan Institute for Food and Drug Control,Kunming 650011,China |
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| Abstract: | Objective To isolate and identify the related substances from raw material of breviscapine.Methods Four related substances were isolated from raw material of breviscapine by reversed -phase preparative HPLC,and their chemical structures were identified by HR -MS and NMR.Results The four related substances were identified as 6 -hydroxykaempferol -7 -O -β-D -glucuronopyranoside (1),apigenin -7 -O -β-D -glucuronide (2),scutellarein (3)and apigenin (4).All compounds were separated from raw material of breviscapine for the first time,and compound 1 was a new related substance from raw material of breviscapine.Conclusion The material basis of breviscapine had been initially clarified,which may provide scientific basis for quality control. |
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| Keywords: | Breviscapine Related substances Isolation Structural elucidation |
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