尿酸与女性冠状动脉粥样硬化性心脏病患者关系的探讨

目的：探讨血清尿酸水平与女性冠状动脉粥样硬化性心脏病（冠心病）的关系。方法：回顾性分析125例疑诊为冠心病的女性患者的临床资料，按照冠状动脉造影的结果分为非冠心病组72例和冠心病组53例，用磷钨酸还原法检测血清尿酸水平，比较两组患者的一般资料和尿酸水平，并应用多元回归的方法分析血清尿酸水平与女性冠心病的关系。结果：非冠心病组和冠心病组的年龄分别为（55.0±8.9）岁、（63.5±7.6）岁，收缩压分别为（124.6±15.7）mm Hg、（133.5±18.9）mm Hg，血清尿酸水平分别为（238.5±60.5）μmol/L、（293.0±98.9）μmol/L。冠心病组的年龄、收缩压及血清尿酸水平较非冠心病组均明显增高（P〈0.01）；Logistic回归显示：除年龄、收缩压外，血清尿酸水平升高也增加女性患冠心病的风险（β=0.01，P〈0.01）。结论：血清尿酸水平增高是女性冠心病的危险因素，女性冠心病患者要注意监测血清尿酸水平，必要时可给予相应的干预措施。

Investigation of Relationship between Serum Uric Acid Levels and Coronary Heart Disease in Women

Objective：To investigate the relationship between serum uric acid levels and coronary heart disease （CHD）in women.Method：The clinical data of 125 women patients with suspected CHD who suspected coronary heart disease were retrospectively analyzed in the study.The patients were divided into two groups according to the results of coronary angiography,72 cases in the no-CHD group and 53 cases in the CHD group.The serum uric acid levels was detected by the phosphotungstic acid reduction method.The general information and uric acid levels were compared between the two groups.The multiple regression analysis was used for investigating the relationship between serum uric acid levels and CHD in women.Result：The age were（55.0±8.9）years old,（63.5±7.6）years old,systolic blood pressure were（124.6±15.7）mm Hg,（133.5±18.9）mm Hg,serum uric acid levels in the non-CHD and the CHD group were（238.5±60.5）μmol/L,（293.0±98.9）μmol/L respectively.The age,systolic blood pressure and serum uric acid levels in patients with the CHD group were significantly higher than those of the non-CHD group（P〈0.01）. Logistic regression analysis showed that the higher serum uric acid levels as well as the age and systolic blood pressure increased the risk of CHD in women（β=0.01,P〈0.01）.Conclusion：The higher serum uric acid levels is a risk factor for the patients with CHD in women and these patients should pay attention to monitoring serum uric acid levels.