| 亚硝酸钠所致大鼠血清甲状腺激素的变化及维生素E和硒对其影响 |
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| 引用本文： | 杨青,王凡.亚硝酸钠所致大鼠血清甲状腺激素的变化及维生素E和硒对其影响[J].中国地方病学杂志,1988(3). |
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| 作者姓名： | 杨青 王凡 |
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| 作者单位： | 白求恩医科大学地方病研究所病理研究室
(杨青)，白求恩医科大学地方病研究所病理研究室(王凡) |
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| 摘 要： | 给大白鼠喂饲克山病病区粮,并分别向病区粮加维生素 E 和硒,观察亚硝酸钠急性中毒情况下各组大鼠血清甲状腺激素的变化。结果表明,亚硝酸钠可干扰甲状腺正常功能,维生素 E 和硒可不同程度地减轻亚硝酸钠的这种毒性作用。提出除低硒外,亚硝酸盐过多及维生素 E 缺乏在克山病发病中可能有重要作用,需要重视。
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| 关 键 词： | 克山病 亚硝酸钠 硒 甲状腺激素 维生素E |
CHANGES OF SERUM THYROID HORMONE INDUCED BY SODIUM NITRITE AND EFFECT OF VITAMIN E AND SELENIUM |
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| Yang Qing Wang Fan.CHANGES OF SERUM THYROID HORMONE INDUCED BY SODIUM NITRITE AND EFFECT OF VITAMIN E AND SELENIUM[J].Chinese Jouranl of Endemiology,1988(3). |
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| Authors: | Yang Qing Wang Fan |
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| Affiliation: | Yang Qing Wang Fan |
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| Abstract: | Under acute NaNO_2 poisoning,the changes of serum thyroid hormone ofrats kept on diet with grains obtained from the endemic region of Keshandisease and the same diet besides adding vitamin E or selenium respectivelywere investigated.By gavage of NaNo_2,the normal thyroid function of the rats kept on grainsfrom the endemic region was disturbed.Vitamin E or Selenium supplementationdepressed the toxic action of NaNo_2 in varying degrees.It is suggested thatthe role of excess of nitrite and poor Vitamin E in occurrence of Keshan dis-ease should be paid more attention,in addition to selenium deficiency. |
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| Keywords: | Keshan disease Sodium nitrite Vitamin E Selenium Thyroid hormone |
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