探讨肺炎支原体感染与儿童咳嗽变异性哮喘发病的关系

目的：探讨肺炎支原体（MP）感染与儿童咳嗽变异性哮喘（CVA）发病的关系。方法：入选86例CVA患儿作为观察组．98例上呼吸道感染患儿作为对照组，采用明胶颗粒凝集试验检测两组患儿血清肺炎支原体IgM（MP—IgM）抗体。同时采用同位素放射免疫法和血球分析仪常规法测定CVA患儿血清总IgE水平和外周血嗜酸粒细胞计数。结果：CVA组MP-IgM阳性率为37.21％，对照组MP-IgM阳性率为20．41％，两组比较，差异有统计学意义（P〈0．01）。MP—IgM阳性的CVA患儿血清总IgE水平及嗜酸粒细胞计数（EOS）均高于MP—IgM阴性的CVA患儿（P〈0．01）。结论：肺炎支原体感染与儿童咳嗽变异性哮喘有密切相关性。

Correlation between mycoplasma pnenumonia infection and cough variant asthma in children

Objective: To determine the relationship between mycoplasma pnenumonia (MP) infection and cough variant asthma (CVA)in children. Methods: 86 children with CVA were selected as the experiment group and 98 children with a-cute upper respiratory infection as the control group.The MP-IgM antibody level was determined by particle agglutination method in both groups and total serum IgE level determined by isotope radioimmunoassay in the CVA group.The count of eosinophils(EOS) was detected by blood cell analyzer in the CVA group. Results: The positive rate of MP-IgM was 37.21% in experiment group and 20.41% in control group with significant difference (P<0.01), The total MP-IgE was markedly higher in MP-IgM positive CVA children than in the MP-IgM negative CVA children (P<0.01). The count of Eosinophies in MP-IgM positive CVA children was more than in MP-IgM negative CVA children (P<0.01). Conclusion:There was close relationship between mycoplasma pnenumonia (MP) infection and cough variant asthma (CVA).