| 16-(m-氯苯氧基)-17,18,19,20失四碳前列腺素F2α的全合成 |
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| 引用本文： | 刘志煜,吴向荣,何煦昌.16-(m-氯苯氧基)-17,18,19,20失四碳前列腺素F2α的全合成[J].药学学报,1985,20(2):140-142. |
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| 作者姓名： | 刘志煜 吴向荣 何煦昌 |
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| 作者单位： | 中国科学院上海有机化学研究所 |
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| 摘 要： | A simplified synthetic method for compound (1) was described. Both α,β-unsaturated ketone and y-lactone of (4)b were reduced with Dibal simultaneously to corresponding allylic hydroxy group and γ-lactol in good yield. Without protecting the hydroxy group, the mixture (6) was transformed to the target compound (1) by the known method.
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| 关 键 词： | 前列腺素F2a类似物 用二异丁基铝氢1 2-加成还原 |
| 收稿时间： | 1984-01-17 |
Synthesis of 16-(m-chlorophenoxy)-17, 18, 19, 20-tetranor-prostaglandin F2 alpha |
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| LIU Zhi-Yu,WU Xiang-Rong and HE Xu-Chang.Synthesis of 16-(m-chlorophenoxy)-17, 18, 19, 20-tetranor-prostaglandin F2 alpha[J].Acta Pharmaceutica Sinica,1985,20(2):140-142. |
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| Authors: | LIU Zhi-Yu WU Xiang-Rong and HE Xu-Chang |
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| Abstract: | A simplified synthetic method for compound (1) was described. Both α,β-unsaturated ketone and y-lactone of (4)b were reduced with Dibal simultaneously to corresponding allylic hydroxy group and γ-lactol in good yield. Without protecting the hydroxy group, the mixture (6) was transformed to the target compound (1) by the known method. |
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| Keywords: | Reduction with Dibal Prostaglandin F2α analogue |
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