| 雌激素保护脑卒中后束缚应激大鼠作用与降钙素基因相关肽的相关性研究 |
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| 引用本文： | 林源绍,邵蓓,Kevin T.O'Byrne,李晓锋,王虹.雌激素保护脑卒中后束缚应激大鼠作用与降钙素基因相关肽的相关性研究[J].中国临床神经科学,2009,17(2):123-127. |
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| 作者姓名： | 林源绍 邵蓓 Kevin T.O'Byrne 李晓锋 王虹 |
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| 作者单位： | 1. 温州医学院附属第一医院脑血管科,325000
2. 英国伦敦大学国王学院神经内分泌实验室SE1 1UL |
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| 基金项目： | 温州市科技局对外合作交流项目 |
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| 摘 要： | 目的:探讨雌激素保护脑卒中后束缚应激(PSR)大鼠作用与降钙素基因相关肽(CGRP)的相关性.方法:雌性SD 大鼠50只,经Open-Field实验评分后随机分成对照组、脑卒中组、束缚组、PSR组及雌激素治疗组,并建立相应模型.观察各组大鼠不同阶段行为学改变,并运用特异性放射免疫分析方法测定各组大鼠外周血,脊髓及前额叶的CGRP样免疫活性(CGRP-LI)物质,观察各组间CGRP-LI的改变.结果:与对照组比较,PSR大鼠Open-Field实验中水平和垂直得分明显减少,外周及中枢CGRP-LI含量明显降低;与PSR组比较,雌激素治疗组大鼠Open-Field实验中得分增加,外周血、脊髓及前额叶CGRP-LI含量较PSR组升高.结论:CGRP水平的上调可能是雌激素对PSR大鼠的保护作用之一.
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| 关 键 词： | 降钙素基因相关肽 脑卒中后应激 雌激素 束缚应激 |
Protective Effects of Estrogen on Poststroke Restraint Rats and Its Correlation with Calcitonin Gene-Related Peptide |
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| LIN Yuan-Shao,SHAO Bei,Kevin T.O'Byrne,LI Xiao-Feng,WANG Hong.Protective Effects of Estrogen on Poststroke Restraint Rats and Its Correlation with Calcitonin Gene-Related Peptide[J].Chinese Journal of Clinical Neurosciences,2009,17(2):123-127. |
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| Authors: | LIN Yuan-Shao SHAO Bei Kevin TO'Byrne LI Xiao-Feng WANG Hong |
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| Affiliation: | LIN Yuan-Shao~1,SHAO Bei~1,Kevin T.O'Byrne~2,LI Xiao-Feng~2,WANG Hong~1 1 Department of Cerebrovascular Disease,the First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China,2 King's College London,School of Biomedical & Health Sciences,Division of Reproduction & Endocrinology London SE1 1UL UK |
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| Abstract: | Aim:To study the role of calcitonin gene-related peptide(CGRP)on protective effects of estrogen on poststroke restraint(PSR)in female rats.Methods:50 female Sprague Dawley rats were randomly divided into control group,stroke group,restraint group,PSR group and estrogen treatment group after the measurement of Open-Field test.Rats in each group were processed according to molding.After the last Open-Field test was done,these rats were sacrificed;blood,spinal cords and frontal lobes were taken,CGRP- like immu... |
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| Keywords: | calcitonin gene-related peptide poststroke restraint stress estrogen restraint stress |
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