Chronic thyroxine treatment activates the 5-HT2A serotonin receptor in the mouse brain |
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| Authors: | Kulikov A V Zubkov E A |
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| Affiliation: | Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Avenue Lavrentyev, 10, 630090 Novosibirsk, Russia. akulikov@ngs.ru |
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| Abstract: | Chronic thyroxine administration (2.0 mg/l, 60 days) significantly increases the 5-HT2A serotonin receptor gene mRNA level in the frontal cortex and augments the frequency of head twitches induced by the receptor agonist DOI (1.0 mg/kg, i.p.) in AKR mice. The result indicates thyroid hormones involvement in 5-HT2A receptor regulation in adult brain. |
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| Keywords: | 5-HT2A receptor mRNA DOI-induced head twitch Thyroxine Mice |
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