几种不同刺激对血管内白细胞粘附的影响

目的：研究几种刺激引起白细胞与内皮细胞粘附的变化。方法：本实验采用脉冲电刺激、缺血再灌、内毒素和白介素-8等物理或药物的作用,观察大鼠肠系膜细静脉内白细胞粘附及白细胞和血管内皮粘附之间的差别。结果：缺血再灌、内毒素、内毒素、脉冲电刺激和白介纱-8（IL-8）作用后肠系膜细静脉白细胞粘附数量比正常组明显增多,IL-8用药后30min细静脉内白细胞粘附数量最多、缺血再灌、内毒素、脉冲电刺激后白细胞粘附数量大致相同。结论：缺血再灌、内毒素、脉冲电刺激能诱导白细胞的粘附作用。造成内皮损伤,IL-8诱导白细胞的粘附作用最强。

Effects of several different irritation factors on leukocytes adhesion in microvessels

Aim:The interrelation of adhesion between leukocyte and endothelium was studied by several irritation factors.Methods:Leukocyte adhesion was observed by impulse electricity irriation,ischemia/reperfusion,endotoxin and IL 8 in venular of rat mesentery.Results:The results showed these irritation factors resulted in a significant increase in the number of leukocytes adhesion along the venular endothelium of rat mesentery.IL 8 leaded to the most increase of leukocytes adhesion.Especially treated by IL 8 for 30 minutes.The number of leukocytes adhesion of the others was approximately identical.Conclusion:The study suggests that impulse electricity irritation,ischemia/reperfusion,endotoxin and IL 8 are able to induce leukocytes and endothelium adhesion,and IL 8 of them has the most effect.