A Comparative Study: Evaluation of Antioxidant Activity of Melatonin and Some Indole Derivatives |
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Authors: | Zeynep Ate?-Alagöz Tulay Coban Sibel Suzen |
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Affiliation: | (1) Faculty of Pharmacy (ECZACILIK), Department of Pharmaceutical Chemistry, Ankara University, Tandogan, Turkey, 06100;(2) Department of Toxicology, Ankara University, Tandogan, Turkey, 06100 |
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Abstract: | To understand antioxidant activity and the role played by melatonin, we have designed and tested several new compounds. We
present the results in terms of structure-activity relationships, focusing on the lack of the methoxy group and the influence
of the amide side chain. Antioxidant activity of melatonin and some new melatonin analogue indole derivatives were investigated,
using lipid peroxidation and superoxide anion radical scavenger activity assays, in rat liver tissue homogenate. Most of the
compounds were found to be very potent inhibitors of malondialdehyde (MDA) formation at 10−3M. Inhibition rates ranged from 75-44 %. However, no significant inhibitory effect was obtained on superoxide anion formation.
Consequently, it can be concluded that these compounds exhibit important LP activity compared to melatonin. |
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