阻塞性黄疸患者并发肾功能损害时血清一氧化氮的变化及其临床意义

目的　探讨阻塞性黄疸患者并发肾功能损害时血清一氧化氮 (NO)的变化及其临床意义。方法　对 2 5例阻塞性黄疸并发肾功能损害患者的血清NO、一氧化氮合成酶 (NOS)活性、BUN和Cr值进行检测 ,并以 2 6例健康者作为正常对照。结果　阻塞性黄疸组BUN和Cr高于正常对照组 (P<0 .0 1 ) ,而NO和NOS则低于正常对照组 (P<0 .0 1 )。相关分析显示 ,NO与BUN和Cr呈负相关关系 ,其相关系数分别为 - 0 .41 9和 - 0 .553(P<0 .0 1 )。结论　阻塞性黄疸并发肾功能损害时其血清NO和NOS下降 ,提示NO在阻塞性黄疸时对肾功能有一定保护作用

Measurement and Significance of Serum Nitric Oxide Level in Patient with Obstructive Jaundice and Renal Dysfunction

Objective To study the change and significance of the serum nitric oxide (NO) level in patient with obstructive jaundice complicated with renal dysfunction. Methods The level of NO, BUN, Cr in serum and the activity of NOS in 25 patients with obstructive jaundice and renal dysfunction and 26 healthy adults was studied.Results The patients' serum NO level and the activity of NOS were significantly lower than those in the control group( P <0.01),whereas the serum BUN and Cr levels were significantly higher than those in control group( P <0.01). The linear correlation analysis showed that the serum NO had a negative correlation between serum BUN and Cr level ( P <0.01). Conclusion The patients with obstructive jaundice and renal dysfunction may lead to the decrease of serum NO level. NO may have some protective effects to the renal function during obstructive jaundice.