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| TLR4在细菌性肺炎老龄大鼠多器官损伤中的表达及意义 | |
| 引用本文： | 李建生,王守富,张慧俭,秦金利,李素云,余海滨,王峰,李亚,刘四化.TLR4在细菌性肺炎老龄大鼠多器官损伤中的表达及意义[J].中国老年学杂志,2011,31(23). |
| 作者姓名： | 李建生 王守富 张慧俭 秦金利 李素云 余海滨 王峰 李亚 刘四化 |
| 作者单位： | 1. 河南中医学院老年医学研究所,河南 郑州,450008 2. 河南省中医药研究院附院心内科 3. 河南省中医院脑血管病科 |
| 基金项目： | 河南省高校新世纪优秀人才支持计划 |
| 摘 要： | 目的 探讨Toll样受体4(TLR4)在老龄大鼠感染性多器官损伤发病中的意义.方法 将大鼠分为老龄对照组、老龄模型组和青年对照组、青年模型组；选用气管插管法注入肺炎克雷伯杆菌,由肺炎导致多器官损伤；采用免疫组织化学和分子生物学技术,观察肺、心、小肠组织TLR4样受体信号转导通路主要相关分子表达变化.结果 老龄模型组和青年模型组肺、心、小肠组织内毒素结合蛋白(LBP)、CD14、TLR4、白介素-1受体相关激酶(IRAK) mRNA和TLR4、肿瘤坏死因子受体相关因子-6(TRAF-6)、核因子-kB(NF-κB)阳性细胞数和/或光密度表达分别较老龄对照组和青年对照组明显增强(P＜0.01或P＜0.05),老龄模型组肺、心、小肠组织TLR4和NF-κB分子表达又较青年模型组增高显著(P＜0.01或P＜0.05).结论 TLR4信号转导介导了老年感染性多器官损伤,并发挥了重要作用. |
| 关 键 词： | 肺炎 多器官损伤 Toll样受体 信号转导 |
Expression and role of Toll like receptor in multiple organ injury induced-by bacterial pneumonia in aged rats |
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| LI Jian-Sheng,WANG Shou-Fu,ZHANG Hui-Jian,et al..Expression and role of Toll like receptor in multiple organ injury induced-by bacterial pneumonia in aged rats[J].Chinese Journal of Gerontology,2011,31(23). | |
| Authors: | LI Jian-Sheng WANG Shou-Fu ZHANG Hui-Jian |
| Affiliation: | LI Jian-Sheng,WANG Shou-Fu,ZHANG Hui-Jian,et al. Geriatrics Department of Henan College of Traditional Chinese Medicine,Zhengzhou 450008,Henan,China |
| Abstract: | Objective To explore the roles of Toll like receptor 4(TLR4) in the infectious multiple organ injury in the aged rats.Methods Male SD rats were selected and the young rats were randomly divided into young control(YCG,n=10) and model groups(YMG,n=15),the elderly rats were divided into aged control(ACG,n=10) and model groups(AMG,n=25).The model was duplicated through the tracheal intubation,injecting with Klebsiella pneumoniae.And immunohistochemistry and molecular biology techniques were performed to detect ... |
| Keywords: | Pneumonia Multiple organ injury Toll like receptor Signal transduction |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
