| 新型杀虫剂吡虫隆的合成 |
| |
| 引用本文： | 苏文杰,王学成,朱 伟,等.新型杀虫剂吡虫隆的合成[J].浙江化工,2014(4):5-6. |
| |
| 作者姓名： | 苏文杰 王学成 朱 伟 等 |
| |
| 作者单位： | 江苏省兽用抗寄生虫药物工程技术研究中心,江苏常州213127 |
| |
| 摘 要： | 以DMF为溶剂，2-氯-5-氨基苯酚和2,3-二氯-5-三氟甲基吡啶在碳酸钾和相转移催化剂作用下，Williamson醚化反应制得醚化物；2,6-二氟苯甲酰胺和草酰氯缩合得到另一个中间体异氰酸酯。最后，醚化物和异氰酸酯在三乙烯二胺（TEDA）催化下加成反应得到吡虫隆，总收率达到90.3%。
|
| 关 键 词： | 威廉逊醚化 相转移催化 异氰酸酯 苯甲酰脲 |
Synthesis of Fluazuron |
| |
| SU Wen-jie,WANG Xue-cheng,ZHU Wei,ZHU Jian-min.Synthesis of Fluazuron[J].Zhejiang Chemical Industry,2014(4):5-6. |
| |
| Authors: | SU Wen-jie WANG Xue-cheng ZHU Wei ZHU Jian-min |
| |
| Affiliation: | (Jiangsu Veterinary A ntiparastics Engineering Research Center, Changzhou,Changzhou 213127,China) |
| |
| Abstract: | Under the effect of potassium carbonate and phase transfer catalyst, etherification was pre-pared from 2-chloro-5-aminophenol via Williamson reaction with 2,3-dichloro-5-（trifluoromethyl）pyridine in DMF, a second intermediate was synthesized from 2,6-difluorbenzamid with oxalyl chloride, finally acyla-tion reaction of etherification with isocyanate in the presence of TEDA provided the target compound-flu-azuron with an overall yield of 90.3%. |
| |
| Keywords: | Williamson reaction phase-transfer catalysis isocyanate benzoylurea |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
