莜面粉对摄食高脂饲料大鼠的血脂、血小板聚集和血粘度的作用

用高脂饲料喂养大鼠１０周，造成高脂血症模型，观察莜莅面粉对血脂、血小板聚集和血液粘度的影响。结果：每鼠每日饲莅面粉６ｇ，可明显抑制血清总胆固醇（ＴＣ）、低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）、甘油三酯（ＴＧ）和致动脉硬化指数（ＡＩ），同时使高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）和抗动脉硬化指数（ＡＡＩ）升高。每鼠每日饲鼓面粉６ｇ，亦可明显抑制ＡＤＰ或胶原诱导的血小板聚集，并显著降低饲高脂食大鼠的血浆粘度和高切变率（２３０ｓ”）以及低切变率（５．７５ｓ－１）下的全血粘度，而对红细胞聚集指数无明显影响。提示，莜面粉对掇食高脂饲料大鼠的高脂血症、血小板聚集性增高和高血粘症有良好的预防作用。

EFFECT OF NAKED OATS FLOUR ON BLOOD LIPIDS,PLATELET AGGREGATION AND BLOOD VISCOSITY IN HIGH FAT DIET-FED RATS

he effect of Nake Oats flour (NOF) on blood lipids,platelet aggre-gation and blood viscosity was studied in male Wistar rats on a high lipidicchow diet for 10 weeks.NOF,6.0g·d-1 per rat,significantly decreased theserum TC,TG,LDL-Cand atherogenic index(AI),but increased HDL-Cand anti-atherogenic index (AAI).NOF, 6.0g·d-1 per rat, also inhibitedplatelet aggregation induced by ADP or collagen,and significantly loweredthe plasma and whole blood viscosity at the shear rate of 5.75s-1 and 230s-1but not significantly altered the red cell aggregation index. These resultsshowed that NOF possessed the preventive effect on hyperlipidemia,plateletaggregation and high blood viscositv.