| ICAM-1在肿瘤中的研究进展 |
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| 引用本文： | 庄敏敏,张云艳.ICAM-1在肿瘤中的研究进展[J].实用肿瘤学杂志,2018,32(1):82-86. |
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| 作者姓名： | 庄敏敏 张云艳 |
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| 作者单位： | 哈尔滨医科大学附属肿瘤医院(哈尔滨 150081) |
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| 摘 要： | 细胞间黏附分子(Intercellular adhesion molecule-1,ICAM-1)又称CD54,是免疫球蛋白超家族的一种跨膜糖蛋白,参与肿瘤细胞免疫调节、血管生成、侵袭和远处转移。国内外诸多研究证明ICAM-1在多种恶性肿瘤中异常高表达,促进了肿瘤的发生、发展并影响其预后,同时对预测个别肿瘤放化疗敏感性有一定的作用。因此ICAM-1可能为恶性肿瘤的诊断和治疗提供参考依据。本文就近年来ICAM-1在恶性肿瘤中的研究做一综述。
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| 关 键 词： | ICAM-1 肿瘤 进展 预后 |
| 收稿时间： | 2017-07-30 |
Research progress of intercellular adhesion molecule-1 in tumor |
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| ZHUANG Minmin,ZHANG Yunyan.Research progress of intercellular adhesion molecule-1 in tumor[J].Journal of Practical Oncology,2018,32(1):82-86. |
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| Authors: | ZHUANG Minmin ZHANG Yunyan |
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| Affiliation: | Harbin Medical University Cancer Hospital,Harbin 150081,China |
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| Abstract: | Intercellular adhesion molecule(ICAM-1),also known as CD54,is a transmembrane glycoprotein of the immunoglobulin superfamily and involved in tumor cell immune regulation,angiogenesis,invasion and distant metastasis.Many studies from domestic and abroad have proved that ICAM-1 is highly expressed in a variety of malignant tumors,which promotes the occurrence,development and prognosis of tumor.ICAM-1 also plays an important role in predicting the chemosensitivity of individual tumors.Therefore,ICAM-1 may provide a reference for the diagnosis and treatment of malignant tumors.This article summarizes effects of ICAM-1 on malignant tumors in recent years. |
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| Keywords: | ICAM-1 Tumor Progress Prognosis |
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