老年性白内障患者脂质过氧化反应的研究

目的 探讨脂质过氧化反应与老年性白内障的发病关系。方法 本文测定了３９例老年性白内障患者晶状体ＭＤＡ含量、ＳＯＤ活力；４８例血浆ＭＤＡ含量、红细胞ＳＯＤ活力，并以１２例正常人对照。结果 老年性白内障患者晶状体内ＭＤＡ含量高于对照组（Ｐ〈０．０５），高于对照组（Ｐ〈０．０１），红细胞ＳＯＤ活力低于显著对照组（Ｐ〈０．０１），机体脂质过氧化水平明显升高。结论 自由基引发的脂质过氧化水平明显升高。结论

Study of lipid peroxidation reaction in senile cataract

Objective To approach the pathogenesis relationship between lipid peroxidation and senile cataract(SC).Methods The malondialdehyde(MDA) contents and superoxide dismutase(SOD) activities of 39 SC lenses and the plasma MDA contents and erythrocyte SOD activities of 48 SC patients(SC group) were determined and compared with that of 12 healthy individuals(control group).Results The MDA contents of the lenses were increased ( P <0.05),the SOD activities of the lenses were decreased( P <0.01) significantly in SC group as compared with that in the control group.The plasma MDA contents were increased( P <0.01),the erythrocyte SOD activities were decreased( P <0.01) significantly in the SC group,as compared with that in the control group.Conclusion The increasing lipid peroxidation lesion induced by free radical and the decreasing antiperoxidation ability were closely related to SC.The peroxidation lesion of lens and the decreasing of antiperoxidation ability was probably resulted from the decreasing of antiperoxidation enzyme activities in whole.