| 胰岛素抵抗在非酒精性脂肪肝发病中的作用 |
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| 引用本文： | 王炳芳,田培营,冯堃,吴福荣,陆永高,杨英.胰岛素抵抗在非酒精性脂肪肝发病中的作用[J].世界华人消化杂志,2010(30). |
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| 作者姓名： | 王炳芳 田培营 冯堃 吴福荣 陆永高 杨英 |
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| 作者单位： | 江苏大学附属昆山医院消化科;复旦大学附属金山医院消化科; |
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| 摘 要： | 目的:探讨胰岛素抵抗(IR)在非酒精性脂肪肝(NAFL)大鼠脂肪肝模型中的作用机制.方法:大鼠随机分为空白对照组,脂肪肝模型对照组(模型+生理盐水组)和脂肪肝实验组(模型+罗格列酮组).其中脂肪肝模型对照组和脂肪肝实验组分别予生理盐水和马来酸罗格列酮干预治疗4wk.观察各组大鼠肝脏大体形态和组织学改变;检测空腹血糖(FPG),空腹血胰岛素水平(FINS),计算胰岛素抵抗指数(IRI);检测血浆ApoCⅡ、ApoCⅢ水平及血浆脂蛋白脂肪酶(LPL)、肝脂肪酶(HL)活性和大鼠肝组织ApoB-100mRNA的表达量.结果:治疗前,脂肪肝组大鼠(包括脂肪肝模型组和脂肪肝实验组)与空白对照组大鼠比较,肝脏组织学改变达到脂肪肝诊断标准,FPG、FINS明显升高(6.46mmol/L±0.75mmol/L,6.61mmol/L±0.45mmol/L vs5.48mmol/L±0.47mmol/L;78.82mU/L±11.13mU/L,78.48mU/L±12.94mU/Lvs40.90mU/L±7.76mU/L),IR也明显升高(22.48±2.81,22.98±3.47vs9.85±1.15),血浆ApoCⅡ水平降低...
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| 关 键 词： | 马来酸罗格列酮 胰岛素抵抗 非酒精性脂肪肝 三酰甘油 极低密度脂蛋白 脂蛋白脂肪酶 载脂蛋白CⅡ |
Role of insulin resistance in the pathogenesis of nonalcoholic fatty liver disease |
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| Bing-Fang Wang,Kun Feng,Fu-Rong Wu,Yong-Gao Lu,Ying Yang.Role of insulin resistance in the pathogenesis of nonalcoholic fatty liver disease[J].World Chinese Journal of Digestology,2010(30). |
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| Authors: | Bing-Fang Wang Kun Feng Fu-Rong Wu Yong-Gao Lu Ying Yang |
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| Affiliation: | Bing-Fang Wang,Kun Feng,Fu-Rong Wu,Yong-Gao Lu,Ying Yang,Department of Gastroenterology,Kunshan Hospital of Jiangsu University,Kunshan 215300,Jiangsu Province,China Pei-Ying Tian,Jinshan Hospital of Fudan University,Shanghai 200540,China |
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| Abstract: | AIM:To investigate the role of insulin resistance(IR) in the pathogenesis of nonalcoholic fatty liver disease in rats. METHODS:Spraque-Dawley rats were randomly divided into normal control group and model group.The model group was fed a highfat cholesterol-rich diet for 8 wk to induce nonalcoholic fatty liver disease and insulin resistance. The model group was further divided randomly into two equal subgroups:model control subgroup and therapeutic subgroup.Physiological saline and rosiglitazone maleate were... |
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