Residual functional connectivity in the split-brain revealed with resting-state functional MRI |
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Authors: | Uddin Lucina Q Mooshagian Eric Zaidel Eran Scheres Anouk Margulies Daniel S Kelly A M Clare Shehzad Zarrar Adelstein Jonathan S Castellanos F Xavier Biswal Bharat B Milham Michael P |
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Affiliation: | New York University Child Study Center, New York, NY 10016, USA. lucina.uddin@med.nyu.edu |
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Abstract: | Split-brain patients present a unique opportunity to address controversies regarding subcortical contributions to interhemispheric coordination. We characterized residual functional connectivity in a complete commissurotomy patient by examining patterns of low-frequency BOLD functional MRI signal. Using independent components analysis and region-of-interest-based functional connectivity analyses, we demonstrate bilateral resting state networks in a patient lacking all major cerebral commissures. Compared with a control group, the patient's interhemispheric correlation scores fell within the normal range for two out of three regions examined. Thus, we provide evidence for bilateral resting state networks in a patient with complete commissurotomy. Such continued interhemispheric interaction suggests that, at least in part, cortical networks in the brain can be coordinated by subcortical mechanisms. |
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