维生素D缺乏与系统性红斑狼疮的相关性研究

目的 探讨系统性红斑狼疮（SLE）患者维生素D缺乏现象与疾病活动性的相关性.方法 选取60例SLE患者及30例健康志愿者,收集研究对象临床资料;ELISA法检测血清25-羟基维生素D25-（OH）D]水平;采用Pearson相关分析法分析血清25-（OH）D水平与SLE疾病活动指数（SLEDAI）、抗ds-DNA抗体滴度、补体C3、补体C4、尿蛋白定量、血清免疫球蛋白G（IgG）的相关性.结果 （1）SLE患者血清25-（OH）D水平36.8（23.4,53.2）nmol/L]较健康志愿者58.8（51.1,65.3） nmol/L]明显降低（P＜0.01）;（2）SLE患者中维生素D缺乏比例为53.3％,严重维生素D缺乏比例为15.0％,健康志愿者中维生素D缺乏比例为23.3％,严重维生素D缺乏比例为6.7％,两组比较差异具有统计学意义（P＜0.01）.（3）SLE患者血清25-（OH）D水平与SLEDAI（r=-0.35,P＜0.05）及抗ds-DNA抗体滴度（r=-0.42,P＜0.05）呈负相关,与补体C3（r=0.25,P＜0.05）、补体C4（r=0.28,P＜0.05）呈正相关,与尿蛋白定量、血清IgG水平无明显相关性（P＞0.05）.结论 SLE患者中维生素D缺乏现象普遍存在,血清维生素D水平与疾病活动性具有一定相关性.

The association of vitamin D deficiency with systemic lupus erythematosus

Objective To explore the association of vitamin D deficiency with systemic lupus erythematosus（SLE）.Methods 60 SLE patients and 30 matched controls were enrolled in this study.Demographic and clinical data were recorded and the serum 25-hydroxyvitamin D 25 （OH） D] levels were measured by ELISA.The correlation between 25 （OH） D levels and SLE disease activity were analyzed by Pearson correlation.Results The levels of serum 25 （OH） D were significantly lower in patients with SLE than in controls 36.8 （23.4,53.2） nmol/L in SLE vs 58.8 （51.1,65.3） nmol/L in control,P ＜ 0.01].The frequencies of vitamin D deficiency and severe vitamin D deficiency among SLE patients were 53.3％and 15.0％ respectively,which were significantly higher than among controls （P ＜ 0.01）.There were negative correlations between serum 25 （OH） D levels and SLE disease activity index （SLEDAI） （r =-0.35,P ＜ 0.05） or anti ds-DNA antibody （r =-0.42,P ＜ 0.05）.Positive correlations existed between serum 25 （OH） D levels and serum C3 （r =0.25,P ＜ 0.05） or C4 （r =0.28,P ＜ 0.05）.No correlation was detected between serum 25 （OH） D levels and urine protein or serum IgG.Conclusion Vitamin D deficiency was common in patients withSLE.The levels of vitamin D were associated with disease activity of SLE.