植物多酚干预肥胖发生作用机制的研究进展

肥胖及其并发症严重危害公众身体健康,且肥胖发病率逐年上升,给社会和个人带来巨大的经济和心理负担。因此,肥胖的预防及治疗在学术界已成为亟待解决的重要问题。植物多酚是植物体内种类最多的一类次生代谢产物,广泛存在于水果、蔬菜、中草药以及植物源食品中,且多酚被报道具有抗氧化、抗炎、抗菌、抗病毒和抗癌等多种生物活性。此外,大量研究表明植物多酚具有良好的预防或治疗肥胖及其并发症的效果。本文从调节机体脂质代谢,影响脂肪细胞的增殖、分化与凋亡,刺激机体产热、加速能量消耗,抗炎和促进益生菌增长以调节肠道菌群等方面系统介绍了植物多酚的减肥降脂作用及其相关机理的研究进展,以期为植物多酚的开发与推广应用提供有益参考。

Research progress on the anti-obestiy effect and mechanism of plant polyphenols

The incidence rates of obesity and its complications are increasing year by year, which seriously endangers human health and brings huge economic burden to the society and individuals. Therefore, the prevention and treatment of obesity has become one of the most important problems to be solved. As a class of natural secondary metabolites, plant polyphenols are widely presented in fruits, vegetables, herbal medicine and plant-derived foods, and possess various bioactivities, including antioxidant, anti-inflammatory, antibacterial, antiviral, anti-cancer and other biological activities. A growing number of studies have shown that plant polyphenols have positive effects in preventing or treating obesity and its complications. This paper introduced the recent research progress on the mechanism of reducing weight and lipid of plant polyphenols from the aspects of regulating lipid metabolism, influencing the proliferation, differentiation and apoptosis of adipocytes, stimulating thermogenesis, anti-inflammatory, and modulating the gut microbiota, in order to provide reference for the utilization of plant polyphenols.