奥曲肽治疗急性胰腺炎临床研究

目的探讨奥曲肽注射液治疗急性胰腺炎的有效性和安全性。方法观察在综合治疗中早期使用奥曲肽注射液治疗急性胰腺炎患者64例效果,与非使用奥曲肽注射液治疗急性胰腺炎75例相比较,监测两组血清淀粉酶含量,同时比较两组并发症的发生率、并发症、住院时间。结果奥曲肽治疗组43例轻症急性胰腺炎(MAP)患者21例重症急性胰腺炎(SAP)患者血清淀粉酶治疗后48h、72h均明显降低,与非奥曲肽治疗组有显著性差异。奥曲肽治疗组平均住院时间为10.3d,非奥曲肽治疗组平均住院时间为15.8d,住院时间明显缩短。奥曲肽治疗组患者发生并发症21次,非奥曲肽治疗组发生并发症43次。结论奥曲肽注射液能有效降低血清和浆膜腔积液淀粉酶活性,能明显改善临床症状,缩短住院时间,减少并发症发生和病死率。

Clinical Studies of Octreotide Treatment of Acute Pancreatitis

Objective To explore the effect and safety of octreotide therapy for the acute pancreatitis. Methods 139 patients with acute pancreatitis were studide, 64 cases were treated early by octreotide during comprehensive treatment, 75 cases were not treated by octreotide, monitor serum amylase, compare the rate of complication and the time of resident. Results The AMS of group were treated by octreotide, including 43 cases with MAP（Mild acute pancreatitis）, 21 cases with SAP（severe acute pancreatitis ） were reduced obviously in 48 hours and 72 hours,the difference comparing the group were not treated by octreotide is obviously The average time of resident in group were treated by octreotide was 10.3 days and 15.8 days in group were not treated by octreotide, 21 cases happen complication in group were treated by octreotide, 43 cases happen complication in group were not treated by octreotide. Coneolusion The octreotide can reduce AMS effectively ,relieve clinical symptom,shorten the time of resident,reduce complication and death rate.