母乳喂养预防呼吸道感染的Meta分析

目的评价母乳喂养对婴儿呼吸道感染的预防保护作用。方法计算机检索中国生物医学文献光盘数据库、中国期刊全文数据库、维普中文科技期刊、万方数字化期刊等数据库。按纳入、排除标准纳入合格文献进行Meta分析,采用RevMan4.2软件进行。结果共纳入17篇研究,并对不同月龄大小的婴儿采用分层分析,分别计算其OR值。Meta分析结果表明,新生儿的母乳喂养组与混合喂养组的在新生儿期呼吸道感染情况的合并OR和95%CI为0.710.31,1.61];6个月的婴儿母乳喂养组与混合喂养组在6个月内感染的合并OR和95%CI为0.580.49,0.70];6个月的婴儿母乳喂养组与人工喂养组的合并OR和95%CI为0.330.22,0.49];一周岁的婴儿母乳喂养组与混合喂养组在一年内感染的合并OR和95%CI为0.980.38,2.49];一周岁的婴儿母乳喂养组与人工喂养组的合并OR和95%CI为0.400.16,1.04]。结论 6个月的婴儿母乳喂养组在6个月期间患呼吸道感染情况要明显低于混合喂养组与人工喂养组,支持母乳喂养对呼吸道感染的保护作用,但同时由于纳入研究的数量少、潜在的发表偏倚和质量不高,新生儿及一周岁婴儿的母乳喂养组未体现明显保护作用。因此,对新生儿期及一周岁婴儿继续开展高质量、大样本的调查非常必要。

Meta-analysis on the effect of breast-feeding in the prevention of respiratory infection

Objective To evaluation the preventive effect of breast-feeding for respiratory infection in infants.Methods We searched China BioMedical literature on disc(CBMdisc),China Journals Full text database,Vip Chinese science and technology journals,Wanfang Digital journals databases.The qualified articles were selected and analyzed by RevMan4.2 software for meta-analysis.Results Seventeen articles were included.Stratified analysis was applied for different months of infants,The OR values were calculated respectively.Meta-analysis showed that the combined OR and 95% CI of the respiratory infections of breast-feeding and the mixed feeding for newborns in the neonatal period was 0.71 0.31,1.61];The combined OR and 95% CI of the respiratory infections of breast-feeding and the mixed feeding in 6 months for infants of 6 months old was 0.58 0.49,0.70];the combined OR and 95% CI of the respiratory infections of breast-feeding and the artificial feeding for infants of 6 months old was 0.33 0.22,0.49];the combined OR and 95% CI of the respiratory infections of breast-feeding and the mixed feeding in one year for infants of 1 year old was 0.98 0.38,2.49];the combined OR and 95% CI of the respiratory infections of breast-feeding and the artificial feeding for infants of 1 year old was 0.40 0.16,1.04].Conclusion The respiratory infections for infants of 6 months old during 6-month period was significantly lower in the breast-feeding group than the mixed-feeding group,proving that breastfeeding playes a protective effect against respiratory infections.But because of insufficient studies,the potential publication bias and the low quality of published articles,newborns and 1-year-old infants in the breast-feeding group did not reflect the significant protective effect.Therefore,it is necessary for newborns and one-year-old babies to continue to carry out high-quality,large sample survey.