| 丹参治疗大鼠肝纤维化的效果观察 |
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| 引用本文： | 张晓燕,舒建昌,何雅军,叶国荣,吕霞.丹参治疗大鼠肝纤维化的效果观察[J].国际中医中药杂志,2008,30(3). |
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| 作者姓名： | 张晓燕 舒建昌 何雅军 叶国荣 吕霞 |
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| 作者单位： | 1. 广州市红十字会医院消化内科,广州,510220
2. 广州市红十字会医院检验科,广州,510220 |
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| 基金项目： | 广东省中医药管理局科研项目，广州市卫生局中医药、中西医结合立项科研课题 |
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| 摘 要： | 目的 观察丹参治疗四氯化碳所致大鼠肝纤维化的效果.方法 采用四氯化碳腹腔注射法制作大鼠肝纤维化模型,给予丹参灌胃处理,同时设立正常组、对照组,检测血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、透明质酸(HA)、层黏连蛋白(LN)、Ⅲ型前胶原(PC-Ⅲ),肝组织行HE和Masson三色胶原染色,光镜下观察肝脏组织病理学变化.结果 较模型组,丹参组能明显降低肝纤维化时异常升高的ALT、AST、HA、LN、PC-Ⅲ(P＜0.01),明显改善四氯化碳所致大鼠肝纤维化的病理学改变.结论 丹参具有治疗大鼠肝纤维化作用.
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| 关 键 词： | 丹参 肝纤维化 治疗 |
Observation on the therapeutic Effects of Hepatic Fibrosis of Rats with Salvia Miltiorrhiza |
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| ZHANG Xiao-yan,SHU Jian-chang,HE Ya-jun,YE Guo-rong,LV Xia.Observation on the therapeutic Effects of Hepatic Fibrosis of Rats with Salvia Miltiorrhiza[J].International Journal of Traditional Chinese Medicine,2008,30(3). |
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| Authors: | ZHANG Xiao-yan SHU Jian-chang HE Ya-jun YE Guo-rong LV Xia |
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| Abstract: | Objective To investigate therapeutic effects of Salvia miltiorrhiza on hepatic fibrosis of rats induced by carbon tewachloridean. Methods Rat models of hepatic fibrosis were founded by intraperitoneal injection of carbon tetrachloride. Salvia miltiorrhiza were given to these rats. Normal group and control group were set for comparison at the same time. Serum levels of ALT, AST, HA, LN, and PC-Ⅲ were detected; HE and Masson staining were conducted in hepatic tissues to observe pathological variations. Results Salvia miltiorrhiza could decrease serum levels of ALT, AST, HA, LN,PC-Ⅲ obviously (P ＜0.01), compared with the control group; Salvia miltiorrhiza could obviously improve pathological variations compared with the control group. Conclusion Salvia miltiorrhiza has therapeutic effect on hepatic fibrosis of rats |
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| Keywords: | Salvia mUtiorrhiza Hepatic fibrosis Treatment |
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