| 白木香果实中的葫芦素（英文） |
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| 引用本文： | 梅文莉,林峰,左文健,王辉,戴好富.白木香果实中的葫芦素（英文）[J].中国天然药物,2012(3):234-237. |
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| 作者姓名： | 梅文莉 林峰 左文健 王辉 戴好富 |
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| 作者单位： | [1]中国热带农业科学院热带生物技术研究所海南省黎药资源天然产物研究与利用重点实验室,海口571101 [2]海口市热带天然产物研究与利用重点实验室,海口571101 |
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| 基金项目： | 海南省重点科技计划项目（No.2010183）,海南省中药现代化专项项目（No.2010ZY005）,海口市重点科技计划项目（No.2010-027）. |
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| 摘 要： | 目的：对白木香果实中的化学成分进行研究。方法：采用硅胶和SephadexLH-20柱色谱等方法对化合物进行分离,根据化合物的理化性质和波谱数据进行鉴定。结果：共分离纯化出5个化合物,其结构分别鉴定为葫芦苦素I（1）、葫芦素I（2）、葫芦素D（3）、异葫芦素D（4）和新葫芦素B（5）。结论：化合物1？5均为首次从沉香属植物中分离得到。化合物1,2,4和5对K562、SGC-7901和SMMC-7721显示有细胞毒活性。
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| 关 键 词： | 白木香 化学成分 葫芦素 细胞毒活性 |
Cucurbitacins from fruits of Aquilaria sinensis |
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| MEI Wen-Li Δ,LIN Feng Δ,ZUO Wen-Jian,WANG Hui,DAI Hao-Fu.Cucurbitacins from fruits of Aquilaria sinensis[J].Chinese JOurnal of Natural Medicines,2012(3):234-237. |
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| Authors: | MEI Wen-Li Δ LIN Feng Δ ZUO Wen-Jian WANG Hui DAI Hao-Fu |
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| Affiliation: | 1Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine,Institute of Tropical Bioscience andBiotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou 571101,China;2Haikou Key Laboratory for Research and Development of Tropical Natural Products,Haikou 571101,China |
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| Abstract: | AIM：To investigate the chemical constituents in the fruits of Aquilaria sinensis.METHODS：The chemical constituentswere isolated by column chromatography on silica gel and Sephadex LH-20,and their structures were elucidated on the basis ofspectroscopic analysis.RESULTS：Five compounds were isolated and identified as hexanorcucurbitacin I（1）,cucurbitacin I（2）,cucurbitacinD（3）,isocucurbitacin D（4）,and neocucurbitacin B（5）.CONCLUSION：Compounds 1.5 were reported from Aquilariagenus for the first time.Compounds 1,2,4,and 5 showed cytotoxic activities against K562,SGC-7901 and SMMC-7721. |
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| Keywords: | Aquilaria sinensis Chemical constituent Cucurbitacin Cytotoxic activity |
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