先天性巨结肠发病的部分影响因素调查

目的 采用调查问卷的方式，对先天性巨结肠患儿母孕期状况及家庭史进行调查分析，探讨先天性巨结肠发病的部分影响因素，以期为防病提供临床参考。方法 对60例先天性巨结肠和40例正常儿童进行统一问卷调查，采用逐步回归分析的方法发现与先天性巨结肠的发病部分可能有关的因素。结果 先天性巨结肠的发病部分可能有关的因素是母孕期被动吸烟状况、患儿性别、母孕期有害物质接触史和家庭恶性肿瘤病史。结论环境和遗传因素与先天性巨结肠的发生有一定关系。

Study on the particular etiology of hirschsprung's disease

Objectives The present study was designed to demonstrate factors which contribute to the etiology of HD. Methods The clinical data and pathogenic data were from 60 families of HD patients and 40 families of normal children.We applied stepwise regression analysis and logistic regression model to analysis the data.Results We found the pathogeny of HD was significantly correlated with 4 factors,they are the passive smoking in pregancy,the sex of patient,the contacting with harmful substance in pregnancy and the tumor history of family.Conclusions Environment and heredity are responsible for the etiology of HD.