| 聚乙二醇干扰素α-2a治疗慢性丙型肝炎病毒／乙型肝炎病毒共感染临床疗效 |
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| 引用本文： | 潘蕾,魏欣,谢玉梅,郝春秋,王九平,贾战生,白雪帆.聚乙二醇干扰素α-2a治疗慢性丙型肝炎病毒／乙型肝炎病毒共感染临床疗效[J].临床肝胆病杂志,2011,27(1):84-85,95. |
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| 作者姓名： | 潘蕾 魏欣 谢玉梅 郝春秋 王九平 贾战生 白雪帆 |
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| 作者单位： | 第四军医大学唐都医院全军感染病诊疗中心,西安,710038 |
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| 基金项目： | 国家“863”专项课题(2007AA02Z441); “十一五”重大传染病防治专项课题(2009ZX10004-715) |
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| 摘 要： | 目的研究慢性丙型肝炎（CHC）与丙型肝炎病毒/乙型肝炎病毒（HCV/HBV）共感染者用聚乙二醇干扰素α-2a（PEG-IFNα-2a）抗病毒治疗疗效的观察。方法治疗前后定期采集31例CHC、30例HCV/HBV共感染者的外周血,检测HCV RNA、HBV DNA和肝脏纤维化指标。结果治疗后CHC患者血清中HCV RNA含量51.6%〈102拷贝/ml,HCV/HBV共感染者HCV、HBV下降均不理想。结论 PEG-IFNα-2a抗病毒治疗HCV/HBV共感染者疗效较单纯丙型肝炎患者差,但对HBV、HCV有抑制作用,并部分改善机体免疫功能及肝功能。
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| 关 键 词： | 肝炎 乙型 慢性 肝炎 丙型 慢性 肝炎病毒属 肝炎病毒 乙型 干扰素α |
Anti-viral therapy with pegylated interferon alpha-2a plus ribavirin in patients co-infected with HBV and HCV |
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| PAN Lei,WEI Xin,XIE Yu-mei,et al..Anti-viral therapy with pegylated interferon alpha-2a plus ribavirin in patients co-infected with HBV and HCV[J].Chinese Journal of Clinical Hepatology,2011,27(1):84-85,95. |
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| Authors: | PAN Lei WEI Xin XIE Yu-mei |
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| Affiliation: | PAN Lei,WEI Xin,XIE Yu-mei,et al.(Center of Diagnosis and Treatment for Infectious Disease of Chinese PLA,Tangdu Hospital,the Fourth Military Medical University,Xi'an 710038,China) |
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| Abstract: | Objective To evaluate the anti-viral therapy with pegylated interferon alpha-2a plus ribavirin in patients co-infected with HBV and HCV.Methods We investigated 31 patients infected with HCV and 30 patients co-infected with HCV and HBV,before and after the anti-viral therapy.HCV RNA,HBV DNA and some biochemical indicators for fibrosis were detected.Results HCV-RNA showed negative in 51.6% of patients with chronic hepatitis C after therapy,but the inhibition rate of HCV RNA was lower in patients co-infected w... |
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| Keywords: | hepatits B chronic hepatitis C hepacivirus hepatitis B virus interferon-alpha |
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