| 天津地区慢性丙型肝炎患者自身抗体的检测结果及临床分析 |
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| 引用本文： | 王春妍,胡东胜,陆伟. 天津地区慢性丙型肝炎患者自身抗体的检测结果及临床分析[J]. 临床肝胆病杂志, 2011, 27(1): 93-95 |
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| 作者姓名： | 王春妍 胡东胜 陆伟 |
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| 作者单位： | 天津市传染病医院,天津市肝病研究所,天津,300192 |
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| 摘 要： | 目的分析天津地区慢性丙型肝炎（CHC）患者血清中自身抗体阳性率及其临床意义。方法选择天津地区98例CHC患者,检测自身抗体（ANA、ASA、AMA、RF、LKM-I）阳性率,并比较自身抗体（＋）及自身抗体（-）群年龄、性别及病毒复制状况。结果 CHC患者血清中自身抗体至少一种阳性的32例,阳性率32.7%。ANA阳性率最高,为26.5%;其次为RF阳性率（8.1%）,再次为AMA阳性率（2.0%）,LC-1及LKM-1阳性率为1.0%。另外,自身抗体阳性组和阴性组有关因素比较发现,阳性组年龄较大（57.1岁vs 46.8岁）,女性多见（65.6%vs 47.0%）。肝脏功能差,免疫功能异常,病毒复制活跃。结论丙型肝炎病毒（HCV）感染者存在自身免疫反应。HCV感染使感染者体内产生多种自身抗体,自身抗体检出率与年龄关系密切且与病毒的复制有关。自身抗体可能是HCV感染后肝组织损伤的重要因素。
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| 关 键 词： | 肝炎,丙型,慢性 自身抗体 |
Detection and clinical significance of autoantibodies In patients with chronic hepatitis C in Tianjin |
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| WANG Chun-yan,HU Dong-sheng,LU Wei. Detection and clinical significance of autoantibodies In patients with chronic hepatitis C in Tianjin[J]. Chinese Journal of Clinical Hepatology, 2011, 27(1): 93-95 |
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| Authors: | WANG Chun-yan HU Dong-sheng LU Wei |
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| Affiliation: | WANG Chun-yan,HU Dong-sheng,LU Wei.(The Contagious Hospital of Tianjin,Tianjin 300192,China) |
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| Abstract: | Objective To analyze the positive incidence and clinical significance of autoantibodies in the serum of patients with chronic hepatitis C in Tianjin.Methods 98 HCV patients were included in this study.The liver specific autoantibodies(ANA,ASA,AMA,RF,LKM-I) were detected by indirect immunofluorescence assay.The factors such as age,gender,and HCV replication were compared between the patients with positive and negative autoantibodies.Results Autoantibodies were detected in 32 individuals(at least one of them ... |
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| Keywords: | hepatitis C chronic autoantibodies |
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